CLCNKB 抗体 (AA 51-150) (Cy5.5)
Quick Overview for CLCNKB 抗体 (AA 51-150) (Cy5.5) (ABIN1705681)
抗原
See all CLCNKB 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 51-150
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预测反应
- Human,Mouse,Rat,Dog,Cow,Pig,Rabbit
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic peptide derived from human CLCNKB
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亚型
- IgG
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anti-Chloride Channel Kb (CLCNKB) (AA 538-687) antibody
CLCNKB 适用: 人 ELISA, WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Chloride Channel Kb (CLCNKB) (N-Term) antibodyCLCNKB 适用: 人 ELISA, WB 宿主: 兔 Polyclonal unconjugated
anti-Chloride Channel Kb (CLCNKB) (N-Term) antibodyCLCNKB 适用: 人, 犬 WB 宿主: 兔 Polyclonal unconjugated
anti-Chloride Channel Kb (CLCNKB) (C-Term) antibodyCLCNKB 适用: 人, 大鼠, 犬, Cow, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Chloride Channel Kb (CLCNKB) (N-Term) antibodyCLCNKB 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Chloride Channel Kb (CLCNKB) (C-Term) antibodyCLCNKB 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
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有效期
- 12 months
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- CLCNKB (Chloride Channel Kb (CLCNKB))
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别名
- CLCNKB
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背景
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Synonyms: Bartter syndrome type 3, Chloride channel Kb, Chloride channel kidney B, Chloride channel protein ClC-Kb, Chloride channel voltage sensitive Kb, ClC K2, ClC-K2, ClCK2, CLCKB, CLCKB_HUMAN, CLCNKB, hClC Kb, hClCKb, MGC24087, OTTHUMP00000011120, OTTHUMP00000011121, RP11 5P18.8.
Background: The family of voltage-dependent chloride channels (CLCs) regulate cellular trafficking of chloride ions, a critical component of all living cells. CLCs regulate excitability in muscle and nerve cells, aid in organic solute transport, and maintain cellular volume. CLC-KA is a kidney-specific chloride channel that mediates transepithelial chloride transport in the thin ascending limb of the Henle loop in the inner medulla. CLC-KA plays a crucial role in urine concentration. The gene encoding human CLC-KA maps to chromosome 1p36. Mutations in this gene may be associated with nephrogenic diabetes insipidus in those cases where mutations in the vasopressin V2 receptor and the AQP2 water channel are lacking. CLC-KB mediates basolateral chloride ion efflux in the thick ascending limb and in more distal nephron segments. The gene encoding human CLC-KB maps to chromosome 1p36. Mutations in this gene cause type III Barter?s syndrome which is characterized by renal salt-wasting and low blood pressure.
抗原
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