TOM1L1 抗体 (AA 1-100) (Cy5.5)
Quick Overview for TOM1L1 抗体 (AA 1-100) (Cy5.5) (ABIN1705515)
抗原
See all TOM1L1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-100
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预测反应
- Human,Cow,Sheep,Pig,Horse,Rabbit
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic peptide derived from human TOM1L1
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亚型
- IgG
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anti-Target of Myb1 (Chicken)-Like 1 (TOM1L1) (AA 296-476) antibody
TOM1L1 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Target of Myb1 (Chicken)-Like 1 (TOM1L1) (C-Term) antibodyTOM1L1 适用: 人 WB, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Target of Myb1 (Chicken)-Like 1 (TOM1L1) antibodyTOM1L1 适用: 人 IHC (f) 宿主: 小鼠 Monoclonal unconjugated
anti-Target of Myb1 (Chicken)-Like 1 (TOM1L1) (AA 276-325) antibodyTOM1L1 适用: 人 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Target of Myb1 (Chicken)-Like 1 (TOM1L1) (AA 1-346) antibodyTOM1L1 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Target of Myb1 (Chicken)-Like 1 (TOM1L1) (Internal Region) antibodyVerified TOM1L1 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
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应用备注
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
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有效期
- 12 months
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- TOM1L1 (Target of Myb1 (Chicken)-Like 1 (TOM1L1))
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别名
- Tom1l1
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背景
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Synonyms: OK/KNS CL.3, Src activating and signaling molecule, Src activating and signaling molecule protein, Src-activating and signaling molecule protein, SRCASM, Target of Myb like protein 1, Target of Myb-like protein 1, Target of myb1 chicken homolog like 1, Target of myb1 chicken like 1, Target of myb1 like 1, TM1L1_HUMAN, TOM1 L1, TOM1 like protein 1, TOM1-like protein 1, TOM1L1, TOM1L1 protein.
Background: Tom1L-1 is a 476 amino acid Golgi apparatus protein belonging to the TOM1 family and is a member of the multivesicular body (MVB) sorting machinery. Containing a GAT domain and a VHS domain, Tom1L-1 interacts with Fyn, GRB2, PI 3-kinase p85?and various signaling proteins when phosphorylated. GAT domain of Tom1L1 binds ubiquitin, suggesting participation in the sorting of ubiquitinated proteins into MVBs. Tom1L-1 may act as an adapter protein involved in signaling pathways and may promote Fyn activation, possibly by disrupting intramolecular SH3-dependent interactions. As an interactor and a substrate of Src tyrosine kinases (SFK), Tom1L1 is considered a novel mechanism involved in negative regulation of SFK mitogenic and transforming signals. Tom1L1 modulates SFK partitioning at the plasma membrane and downregulates Src kinases in an endosomal-dependent manner. It is suggested that Tom1L-1 functions as an anti-oncogene by inhibiting the formation of squamous cell carcinomas in skin.
抗原
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