FFAR1 抗体 (AA 121-220) (Cy3)
Quick Overview for FFAR1 抗体 (AA 121-220) (Cy3) (ABIN1702937)
抗原
See all FFAR1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 121-220
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交叉反应
- 人, 小鼠
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预测反应
- Rat,Dog,Pig
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic peptide derived from human GPR40
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亚型
- IgG
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应用备注
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
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有效期
- 12 months
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- FFAR1 (Free Fatty Acid Receptor 1 (FFAR1))
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别名
- GPR40
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背景
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Synonyms: FFA1R, GPR40, GPCR40, Free fatty acid receptor 1, G-protein coupled receptor 40, FFAR1
Background: G-protein coupled receptor for medium and long chain saturated and unsaturated fatty acids that plays an important role in glucose homeostasis. Fatty acid binding increases glucose-stimulated insulin secretion, and may also enhance the secretion of glucagon-like peptide 1 (GLP-1). May also play a role in bone homeostasis, receptor signaling activates pathways that inhibit osteoclast differentiation (By similarity). Ligand binding leads to a conformation change that triggers signaling via G-proteins that activate phospholipase C, leading to an increase of the intracellular calcium concentration. Seems to act through a G(q) and G(i)-mediated pathway.
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基因ID
- 2864
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UniProt
- O14842
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途径
- Positive Regulation of Peptide Hormone Secretion, Hormone Transport, Peptide Hormone Metabolism, Carbohydrate Homeostasis
抗原
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