FANCC 抗体 (AA 61-160) (Biotin)
Quick Overview for FANCC 抗体 (AA 61-160) (Biotin) (ABIN1700940)
抗原
See all FANCC 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 61-160
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交叉反应
- 人
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预测反应
- Mouse,Rat,Dog,Horse
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic peptide derived from human FANCC
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亚型
- IgG
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anti-Fanconi Anemia, Complementation Group C (FANCC) (AA 319-558) antibody
FANCC 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Fanconi Anemia, Complementation Group C (FANCC) (AA 1-558) antibodyFANCC 适用: 人 WB, IF, IP 宿主: 兔 Polyclonal unconjugated
anti-Fanconi Anemia, Complementation Group C (FANCC) (Center) antibodyFANCC 适用: 人, 小鼠 WB, IF, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-Fanconi Anemia, Complementation Group C (FANCC) (AA 1-210) antibodyFANCC 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Fanconi Anemia, Complementation Group C (FANCC) (AA 1-100) antibodyFANCC 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 6E7 unconjugated
anti-Fanconi Anemia, Complementation Group C (FANCC) (C-Term) antibodyFANCC 适用: 人 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Fanconi Anemia, Complementation Group C (FANCC) (AA 527-555), (C-Term) antibodyFANCC 适用: 人 WB, IF, FACS, IHC (p) 宿主: 兔 Polyclonal RB24076 unconjugated
anti-Fanconi Anemia, Complementation Group C (FANCC) (AA 529-558), (C-Term) antibodyFANCC 适用: 人 WB, IF, FACS, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
anti-Fanconi Anemia, Complementation Group C (FANCC) (N-Term) antibodyFANCC 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Fanconi Anemia, Complementation Group C (FANCC) (AA 1-558) antibodyFANCC 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
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应用备注
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WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C for 12 months.
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有效期
- 12 months
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- FANCC (Fanconi Anemia, Complementation Group C (FANCC))
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别名
- FANCC
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背景
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Synonyms: bA80I15.1, FA 3, FA3, FAC, FACC, FANCC, FANCC_HUMAN, Fanconi anemia complementation group C, Fanconi anemia complementation group C protein, Fanconi anemia group C protein, Fanconi pancytopenia type 3, FLJ14675, Protein FACC.
Background: Fanconi anemia (FA) is an autosomal recessive disorder characterized by bone marrow failure, birth defects and chromsomal instability (1,2). The FA Group C complementation group gene encodes the protein FANCC, which is located in both cytoplasmic and nuclear compartments. FANCC is expressed in a cell cycle-dependent manner, with the lowest levels at the G1/S boundary and the highest levels in the M-phase. The FANCC protein interacts with other FA complementation group proteins as well as non-FA proteins (3). A human a spectrin II (designated aSpIIs) acts as a scaffold to enhance interactions between FANCC and FANCA to form a nuclear complex (4,5). Another binding partner of FANCC is the BTB/POZ domain containing protein FAZF, which is a transcriptional repressor (6). In hematopoietic cells expressing mutant FANCC, PKR is constitutively phosphorylated and has increased binding affinity for double-stranded RNA (7,8), which suggests that FANCC indirectly suppresses the activity of PKR. These cells are also apoptotic and are hypersensitive to IFNg and TNFa (8). In addition, FANCC protein is involved in the activation of STAT1 through receptors for at least three hematopoietic growth and survival factors (8).
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基因ID
- 2176
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途径
- DNA Damage Repair
抗原
-
