FAN1 抗体 (AbBy Fluor® 647)
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- 抗原 See all FAN1 抗体
- FAN1 (FANCD2/FANCI-Associated Nuclease 1 (FAN1))
- 适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This FAN1 antibody is conjugated to AbBy Fluor® 647
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应用范围
- Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- 纯化方法
- Purified by Protein A.
- 免疫原
- KLH conjugated synthetic peptide derived from human FAN1
- 亚型
- IgG
- Top Product
- Discover our top product FAN1 Primary Antibody
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anti-FANCD2/FANCI-Associated Nuclease 1 (FAN1) (AA 1-533) antibody
FAN1 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-FANCD2/FANCI-Associated Nuclease 1 (FAN1) (AA 167-373) antibodyFAN1 适用: 人 ELISA, WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-FANCD2/FANCI-Associated Nuclease 1 (FAN1) antibodyFAN1 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-FANCD2/FANCI-Associated Nuclease 1 (FAN1) (AA 146-174), (N-Term) antibodyFAN1 适用: 人 WB, FACS 宿主: 兔 Polyclonal RB26526 unconjugated
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- 应用备注
- IF(IHC-P) 1:50-200
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 μg/μL
- 缓冲液
- Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- 储存条件
- 4 °C
- 储存方法
- Store at 4°C
- 有效期
- 12 months
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- 抗原
- FAN1 (FANCD2/FANCI-Associated Nuclease 1 (FAN1))
- 别名
- Fan1 (FAN1 产品)
- 背景
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Nuclease required for the repair of DNA interstrand cross-links (ICL) recruited at sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL-induced DNA breaks by being required for efficient homologous recombination, probably in the resolution of homologous recombination intermediates (PubMed:20603015, PubMed:20603016, PubMed:20603073, PubMed:20671156, PubMed:24981866, PubMed:25430771). Not involved in DNA double-strand breaks resection (PubMed:20603015, PubMed:20603016). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Probably keeps excising with 3'-flap annealing until it reaches and unhooks the ICL (PubMed:25430771). Acts at sites that have a 5'-terminal phosphate anchor at a nick or a 1- or 2-nucleotide flap and is augmented by a 3' flap (PubMed:25430771). Also has endonuclease activity toward 5'-flaps (PubMed:20603015, PubMed:20603016, PubMed:24981866).
Subcellular location: Nucleus
Synonyms: KMIN, hFAN1, MTMR15, KIAA1018, Fanconi-associated nuclease 1, FANCD2/FANCI-associated nuclease 1, Myotubularin-related protein 15, FAN1
- 基因ID
- 22909
- UniProt
- Q9Y2M0
- 途径
- DNA Damage Repair
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