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FAN1 抗体 (AbBy Fluor® 647)

FAN1 适用: 人, 小鼠, 大鼠 IF (p) 宿主: 兔 Polyclonal AbBy Fluor® 647
产品编号 ABIN1698843
发货至: 中国
  • 抗原 See all FAN1 抗体
    FAN1 (FANCD2/FANCI-Associated Nuclease 1 (FAN1))
    适用
    人, 小鼠, 大鼠
    宿主
    • 35
    • 2
    克隆类型
    • 37
    多克隆
    标记
    • 10
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This FAN1 antibody is conjugated to AbBy Fluor® 647
    应用范围
    • 14
    • 12
    • 11
    • 7
    • 4
    • 3
    • 3
    • 1
    • 1
    Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    纯化方法
    Purified by Protein A.
    免疫原
    KLH conjugated synthetic peptide derived from human FAN1
    亚型
    IgG
    Top Product
    Discover our top product FAN1 Primary Antibody
  • 应用备注
    IF(IHC-P) 1:50-200
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 μg/μL
    缓冲液
    Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    储存条件
    4 °C
    储存方法
    Store at 4°C
    有效期
    12 months
  • 抗原
    FAN1 (FANCD2/FANCI-Associated Nuclease 1 (FAN1))
    别名
    Fan1 (FAN1 产品)
    背景

    Nuclease required for the repair of DNA interstrand cross-links (ICL) recruited at sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL-induced DNA breaks by being required for efficient homologous recombination, probably in the resolution of homologous recombination intermediates (PubMed:20603015, PubMed:20603016, PubMed:20603073, PubMed:20671156, PubMed:24981866, PubMed:25430771). Not involved in DNA double-strand breaks resection (PubMed:20603015, PubMed:20603016). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Probably keeps excising with 3'-flap annealing until it reaches and unhooks the ICL (PubMed:25430771). Acts at sites that have a 5'-terminal phosphate anchor at a nick or a 1- or 2-nucleotide flap and is augmented by a 3' flap (PubMed:25430771). Also has endonuclease activity toward 5'-flaps (PubMed:20603015, PubMed:20603016, PubMed:24981866).

    Subcellular location: Nucleus

    Synonyms: KMIN, hFAN1, MTMR15, KIAA1018, Fanconi-associated nuclease 1, FANCD2/FANCI-associated nuclease 1, Myotubularin-related protein 15, FAN1

    基因ID
    22909
    UniProt
    Q9Y2M0
    途径
    DNA Damage Repair
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