FAN1 抗体 (AbBy Fluor® 555)
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北京 101111
Quick Overview for FAN1 抗体 (AbBy Fluor® 555) (ABIN1697032)
抗原
See all FAN1 抗体适用
宿主
克隆类型
标记
应用范围
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic peptide derived from human FAN1
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亚型
- IgG
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anti-FANCD2/FANCI-Associated Nuclease 1 (FAN1) (AA 1-533) antibody
FAN1 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-FANCD2/FANCI-Associated Nuclease 1 (FAN1) (AA 167-373) antibodyFAN1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-FANCD2/FANCI-Associated Nuclease 1 (FAN1) antibodyFAN1 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-FANCD2/FANCI-Associated Nuclease 1 (FAN1) (AA 146-174), (N-Term) antibodyFAN1 适用: 人 WB, FACS 宿主: 兔 Polyclonal RB26526 unconjugated
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应用备注
- IF(IHC-P) 1:50-200
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- Store at 4°C
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有效期
- 12 months
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- FAN1 (FANCD2/FANCI-Associated Nuclease 1 (FAN1))
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别名
- Fan1
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背景
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Nuclease required for the repair of DNA interstrand cross-links (ICL) recruited at sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL-induced DNA breaks by being required for efficient homologous recombination, probably in the resolution of homologous recombination intermediates (PubMed:20603015, PubMed:20603016, PubMed:20603073, PubMed:20671156, PubMed:24981866, PubMed:25430771). Not involved in DNA double-strand breaks resection (PubMed:20603015, PubMed:20603016). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Probably keeps excising with 3'-flap annealing until it reaches and unhooks the ICL (PubMed:25430771). Acts at sites that have a 5'-terminal phosphate anchor at a nick or a 1- or 2-nucleotide flap and is augmented by a 3' flap (PubMed:25430771). Also has endonuclease activity toward 5'-flaps (PubMed:20603015, PubMed:20603016, PubMed:24981866).
Subcellular location: Nucleus
Synonyms: KMIN, hFAN1, MTMR15, KIAA1018, Fanconi-associated nuclease 1, FANCD2/FANCI-associated nuclease 1, Myotubularin-related protein 15, FAN1
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基因ID
- 22909
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UniProt
- Q9Y2M0
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途径
- DNA Damage Repair
抗原
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