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GIT1 抗体 (AA 375-770)

GIT1 适用: 大鼠 WB, IP, IF, ICC 宿主: 小鼠 Monoclonal S39B-8 unconjugated
产品编号 ABIN1686622
发货至: 中国
  • 抗原 See all GIT1 抗体
    GIT1
    抗原表位
    • 15
    • 15
    • 15
    • 15
    • 12
    • 8
    • 6
    • 6
    • 6
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 375-770
    适用
    • 73
    • 43
    • 34
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    大鼠
    宿主
    • 101
    • 14
    小鼠
    克隆类型
    • 93
    • 22
    单克隆
    标记
    • 37
    • 9
    • 9
    • 8
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    This GIT1 antibody is un-conjugated
    应用范围
    • 86
    • 39
    • 39
    • 38
    • 19
    • 17
    • 17
    • 16
    • 14
    • 13
    • 9
    • 2
    • 2
    • 2
    • 2
    • 1
    Western Blotting (WB), Immunoprecipitation (IP), Immunofluorescence (IF), Immunocytochemistry (ICC)
    特异性
    Detects ~90 kDa. Does not cross-react with GIT2.
    交叉反应
    人, 小鼠, 大鼠
    纯化方法
    Protein G Purified
    免疫原
    Fusion protein amino acids 375-770 (C-terminus) of rat GIT1
    克隆位点
    S39B-8
    亚型
    IgG1
    Top Product
    Discover our top product GIT1 Primary Antibody
  • 应用备注
    • WB (1:1000)
    • optimal dilutions for assays should be determined by the user.
    说明

    1 μg/ml of ABIN1686622 was sufficient for detection of GIT1 in 10 μg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 mg/mL
    缓冲液
    PBS pH 7.4, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    -20°C
  • 抗原
    GIT1
    别名
    GIT1 (GIT1 产品)
    别名
    Cat-1 antibody, p95Cat antibody, GIT ArfGAP 1 antibody, G protein-coupled receptor kinase interacting ArfGAP 1 antibody, G protein-coupled receptor kinase-interactor 1 antibody, GIT1 antibody, Git1 antibody
    背景
    G-protein coupled receptor (GPCR) kinase interacting proteins 1 and 2 (GIT-1 and GIT-2) are highly conserved, ubiquitous scaffold proteins involved in localized signaling to help regulate focal contact assembly and cytoskeletal dynamics. GIT proteins contain multiple interaction domains that allow interaction with small GTPases (including ARF, Rac and cdc42), kinases (such as PAK and MEK), the Rho family GEF PIX, and the focal adhesion protein paxillin (reviewed in 1). GIT-1 is localized to focal adhesions, cytoplasmic complexes and membrane protrusions, and regulates cell protrusion formation and cell migration (2). GIT-1 has also been implicated in neuronal functions including synapse formation (3) and the pathology of Huntington disease (4). Huntington disease is a genetic neurodegenerative condition involving a mutation in the huntington gene. The huntington gene product (htt) is ubiquitinated and degraded in human Huntington disease brains (5). Htt interacts directly with GIT-1 causing enhanced htt proteolysis, indicating that GIT-1 distribution and function may contribute to Huntington disease pathology (4).
    基因ID
    83709
    NCBI登录号
    NP_114002
    UniProt
    Q9Z272
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