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WISP1 抗体 (AA 158-367)

This anti-WISP1 antibody is a 兔 多克隆 antibody detecting WISP1 in WB. Suitable for 人.
产品编号 ABIN1683290
发货至: 中国

Quick Overview for WISP1 抗体 (AA 158-367) (ABIN1683290)

抗原

See all WISP1 抗体
WISP1 (WNT1 Inducible Signaling Pathway Protein 1 (WISP1))

适用

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宿主

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克隆类型

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多克隆

标记

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This WISP1 antibody is un-conjugated

应用范围

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Western Blotting (WB)
  • 抗原表位

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    AA 158-367

    序列

    LRVRPPRLWC PHPRRVSIPG HCCEQWVCED DAKRPRKTAP RDTGAFDAVG EVEAWHRNCI AYTSPWSPCS TSCGLGVSTR ISNVNAQCWP EQESRLCNLR PCDVDIHTLI KAGKKCLAVY QPEASMNFTL AGCISTRSYQ PKYCGVCMDN RCCIPYKSKT IDVSFQCPDG LGFSRQVLWI NACFCNLSCR NPNDIFADLE SYPDFSEIAN

    交叉反应

    人, 小鼠

    产品特性

    Polyclonal Antibodies

    免疫原

    Recombinant fusion protein containing a sequence corresponding to amino acids 158-367 of human WISP1 (NP_003873.1).

    亚型

    IgG
  • 应用备注

    WB,1:500 - 1:2000

    限制

    仅限研究用
  • 缓冲液

    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    Store at -20°C. Avoid freeze / thaw cycles.
  • 抗原

    WISP1 (WNT1 Inducible Signaling Pathway Protein 1 (WISP1))

    别名

    WISP1

    背景

    This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like domain. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. It is expressed at a high level in fibroblast cells, and overexpressed in colon tumors. The encoded protein binds to decorin and biglycan, two members of a family of small leucine-rich proteoglycans present in the extracellular matrix of connective tissue, and possibly prevents the inhibitory activity of decorin and biglycan in tumor cell proliferation. It also attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase. It is 83 % identical to the mouse protein at the amino acid level. Multiple alternatively spliced transcript variants have been identified.,WISP1,CCN4,WISP1c,WISP1i,WISP1tc,Epigenetics & Nuclear Signaling,DNA Damage & Repair,Stem Cells,WISP1

    分子量

    13 kDa/16 kDa/21 kDa/30 kDa/40 kDa

    基因ID

    8840

    UniProt

    O95388

    途径

    WNT signaling, Growth Factor Binding
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