LARP1 抗体
Quick Overview for LARP1 抗体 (ABIN3019027)
抗原
See all LARP1 抗体适用
宿主
克隆类型
标记
应用范围
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交叉反应
- 人
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产品特性
- Polyclonal Antibodies
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免疫原
- Recombinant Protein of human LARP1
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亚型
- IgG
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anti-La Ribonucleoprotein Domain Family, Member 1 (LARP1) antibody
LARP1 适用: 人, 小鼠, 大鼠 WB, IF, IHC 宿主: 兔 Polyclonal unconjugated
anti-La Ribonucleoprotein Domain Family, Member 1 (LARP1) (AA 1-1019) antibodyLARP1 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-La Ribonucleoprotein Domain Family, Member 1 (LARP1) (AA 107-156) antibodyLARP1 适用: 人, 兔, Cow, 犬, 豚鼠, 马, Bat WB 宿主: 兔 Polyclonal unconjugated
anti-La Ribonucleoprotein Domain Family, Member 1 (LARP1) (AA 36-85) antibodyLARP1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-La Ribonucleoprotein Domain Family, Member 1 (LARP1) (N-Term) antibodyLARP1 适用: 人, 小鼠, 兔, 大鼠, Cow, 犬, 豚鼠, 马 WB 宿主: 兔 Polyclonal unconjugated
anti-La Ribonucleoprotein Domain Family, Member 1 (LARP1) (N-Term) antibodyLARP1 适用: 人, 兔 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB,1:500 - 1:2000
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限制
- 仅限研究用
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缓冲液
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
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- LARP1 (La Ribonucleoprotein Domain Family, Member 1 (LARP1))
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别名
- LARP1
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背景
- RNA-binding protein that regulates the translation of specific target mRNA species downstream of the mTORC1 complex, in function of growth signals and nutrient availability. Interacts on the one hand with the 3' poly-A tails that are present in all mRNA molecules, and on the other hand with the 7-methylguanosine cap structure of mRNAs containing a 5' terminal oligopyrimidine (5'TOP motif, which is present in mRNAs encoding ribosomal proteins and several components of the translation machinery. The interaction with the 5' end of mRNAs containing a 5'TOP motif leads to translational repression by preventing the binding of EIF4G1. When mTORC1 is activated, LARP1 is phosphorylated and dissociates from the 5' untranslated region (UTR of mRNA. Does not prevent binding of EIF4G1 to mRNAs that lack a 5'TOP motif. Interacts with the free 40S ribosome subunit and with ribosomes, both monosomes and polysomes. Under normal nutrient availability, interacts primarily with the 3' untranslated region (UTR of mRNAs encoding ribosomal proteins and increases protein synthesis. Associates with actively translating ribosomes and stimulates translation of mRNAs containing a 5'TOP motif, thereby regulating protein synthesis, and as a consequence, cell growth and proliferation. Stabilizes mRNAs species with a 5'TOP motif, which is required to prevent apoptosis.,LARP1,LARP,Epigenetics & Nuclear Signaling,RNA Binding,LARP1
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分子量
- 116 kDa/123 kDa
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基因ID
- 23367
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UniProt
- Q6PKG0
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途径
- SARS-CoV-2 Protein Interactome, The Global Phosphorylation Landscape of SARS-CoV-2 Infection
抗原
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