VEGFC 抗体
Quick Overview for VEGFC 抗体 (ABIN1589951)
抗原
See all VEGFC 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- VEGF-C antibody
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特异性
- Recombinant human VEGF-C
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交叉反应
- 大鼠
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交叉反应 （详细）
- This antibody detects human and rat VEGF-C in Western blots. No cross-reactivity is shown with VEGF-A.
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产品特性
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Chromosomal location: 11q13
This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse immunized with recombinant human VEGF-C recombinant protein). -
纯化方法
- The IgG2a fraction of culture supernatant was purified by Protein G affinity chromatography.
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免疫原
- Recombinant human VEGF-C
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亚型
- IgG2a
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anti-Vascular Endothelial Growth Factor C (VEGFC) (AA 108-223) antibody
VEGFC 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Vascular Endothelial Growth Factor C (VEGFC) (AA 321-415) antibodyVEGFC 适用: 人, 小鼠, 大鼠 WB, ELISA, FACS, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Vascular Endothelial Growth Factor C (VEGFC) (AA 20-49) antibodyVEGFC 适用: 人 WB, IHC, ELISA, FACS 宿主: 兔 Polyclonal unconjugated
anti-Vascular Endothelial Growth Factor C (VEGFC) (AA 20-49), (N-Term) antibodyVEGFC 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB11713 unconjugated
anti-Vascular Endothelial Growth Factor C (VEGFC) (AA 108-223) antibodyVEGFC 适用: 大鼠 WB 宿主: 小鼠 Monoclonal D3 unconjugated
anti-Vascular Endothelial Growth Factor C (VEGFC) (AA 112-227) antibodyVEGFC 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Vascular Endothelial Growth Factor C (VEGFC) (AA 1-290) antibodyVEGFC 适用: 人 WB, IHC, IHC (p) 宿主: 小鼠 Monoclonal unconjugated
anti-Vascular Endothelial Growth Factor C (VEGFC) (AA 47-413) antibodyVEGFC 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Vascular Endothelial Growth Factor C (VEGFC) (AA 27-57), (N-Term) antibodyVEGFC 适用: 人 WB, FACS, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
anti-Vascular Endothelial Growth Factor C (VEGFC) antibodyVEGFC 适用: 人, 小鼠, 大鼠 WB 宿主: 小鼠 Monoclonal 7C4 unconjugated
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应用备注
- Western Blot: Use at 1-5 μg/mL, IHC: Use at 2-10 μg/mL
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/mL.
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缓冲液
- PBS
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注意事项
- Centrifuge vial prior to opening.
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储存条件
- 4 °C,-20 °C
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储存方法
- The lyophilized antibody is stable for at least 2 years at -20°C. After sterile reconstitution the antibody is stable at 2-8°C for up to 6 months. Frozen aliquots are stable for at least 6 months when stored at -20°C. Addition of a carrier protein or 50% glycerol is recommended for frozen aliquots.
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有效期
- 24 months
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- VEGFC (Vascular Endothelial Growth Factor C (VEGFC))
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别名
- VEGF-C
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背景
- Vascular endothelial growth factor C, VEGFC, VRP, Flt4-L,VEGF-C, also known as Vascular Endothelial Growth Factor Related Protein (VRP), is a recently discovered VEGF growth factor family member that is most closely related to VEGF-D. The human VEGF-C cDNA encodes a pre-pro-protein of 416 amino acids residues. It is almost identical to the mouse VEGF-C protein. Similar to VEGF-D, VEGF-C has a VEGF homology domain spanning the middle third of the precursor molecule and long N- and C-terminal extensions. In adults, VEGF-C is highly expressed in heart, placenta, ovary and small intestine. Recombinant human VEGF-C, lacking the N- and C-terminal extensions and containing only the middle VEGF homology domain, forms primarily non-covalently linked dimers. This protein is a ligand for both VEGFR-2/KDR and VEGFR-3/FLT-4. Since VEGFR-3 is strongly expressed in lymphatic endothelial cells, it has been postulated that VEGF-C is involved in the regulation of the growth and/or differentiation of lymphatic endothelium. Although recombinant human VEGF-C is also a mitogen for vascular endothelial cells, it is much less potent than VEGF-A. The recombinant human VEGF-C contains 115 amino acids residues and was fused to a His-tag (6x His) at the C-terminal end. As a result of glycosylation VEGF-C migrates as an 18-24 kDa protein in SDS-PAGE under reducing conditions.
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基因ID
- 7424
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NCBI登录号
- NM_005429, NP_005420
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UniProt
- P49767
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途径
- RTK signaling, Signaling Events mediated by VEGFR1 and VEGFR2
抗原
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