LYVE1 抗体
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Quick Overview for LYVE1 抗体 (ABIN1589924)
抗原
See all LYVE1 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- Lyve-1 antibody
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特异性
- Recombinant mouse soluble Lyve-1
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产品特性
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Chromosomal location: 7, 7F2
Produced from sera of rabbits immunized with highly pure recombinant mouse soluble LYVE-1 produced in insect cells. The recombinant soluble LYVE-1 consists of amino acid 24 (Ala) to 228 (Gly) and is fused to a C-terminal His-tag (6xHis). -
纯化方法
- Protein-A purified
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免疫原
- Recombinant mouse soluble Lyve-1 (ABIN1589750)
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亚型
- IgG
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anti-Lymphatic Vessel Endothelial Hyaluronan Receptor 1 (LYVE1) (AA 231-318) antibody
LYVE1 适用: 人, 小鼠 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Lymphatic Vessel Endothelial Hyaluronan Receptor 1 (LYVE1) (AA 46-77), (N-Term) antibodyLYVE1 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB2930 unconjugated
anti-Lymphatic Vessel Endothelial Hyaluronan Receptor 1 (LYVE1) (AA 20-238) antibodyLYVE1 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Lymphatic Vessel Endothelial Hyaluronan Receptor 1 (LYVE1) antibodyLYVE1 适用: 人 WB, FACS, ICC 宿主: 兔 Monoclonal 24GB340 unconjugated Recombinant Antibody
anti-Lymphatic Vessel Endothelial Hyaluronan Receptor 1 (LYVE1) (AA 24-228) antibodyLYVE1 适用: 小鼠, 大鼠 WB, ELISA, IHC, FACS 宿主: 兔 Polyclonal unconjugated
anti-Lymphatic Vessel Endothelial Hyaluronan Receptor 1 (LYVE1) (AA 20-238) antibodyLYVE1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Lymphatic Vessel Endothelial Hyaluronan Receptor 1 (LYVE1) (AA 25-235) antibodyLYVE1 适用: 人 WB, ELISA, IF, ICC 宿主: 小鼠 Monoclonal 4G1 unconjugated
anti-Lymphatic Vessel Endothelial Hyaluronan Receptor 1 (LYVE1) antibodyLYVE1 适用: 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Lymphatic Vessel Endothelial Hyaluronan Receptor 1 (LYVE1) antibodyLYVE1 适用: 小鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Lymphatic Vessel Endothelial Hyaluronan Receptor 1 (LYVE1) (N-Term) antibodyLYVE1 适用: 人, 豚鼠 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
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应用备注
- Western Blot: use at 2-5 μg/mL, FACS: use at 3-10 μg/mL, IF/IHC: applicable with cryo-sections.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/mL.
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缓冲液
- PBS
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注意事项
- Centrifuge vial prior to opening.
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储存条件
- 4 °C,-20 °C
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储存方法
- The lyophilized antibody is stable for at least 2 years at -20°C. After sterile reconstitution the antibody is stable at 2-8°C for up to 6 months. Frozen aliquots are stable for at least 6 months when stored at -20°C. Addition of a carrier protein or 50% glycerol is recommended for frozen aliquots.
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有效期
- 24 months
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: "The lymphatic vascular system of the mouse head." in: Cell and tissue research, (2016) (PubMed).
: "Medicinal facilities to B16F10 melanoma cells for distant metastasis control with a supramolecular complex by DEAE-dextran-MMA copolymer/paclitaxel." in: Drug delivery and translational research, Vol. 5, Issue 1, pp. 38-50, (2015) (PubMed).
: "TGF-?1-induced EMT promotes targeted migration of breast cancer cells through the lymphatic system by the activation of CCR7/CCL21-mediated chemotaxis." in: Oncogene, (2015) (PubMed).
: "Endothelial, but not smooth muscle, peroxisome proliferator-activated receptor ?/? regulates vascular permeability and anaphylaxis." in: The Journal of allergy and clinical immunology, Vol. 135, Issue 6, pp. 1625-35.e5, (2015) (PubMed).
: "Arterial wall lymphangiogenesis is increased in the human iliac atherosclerotic arteries: involvement of CCR7 receptor." in: Lymphatic research and biology, Vol. 12, Issue 4, pp. 222-31, (2014) (PubMed).
: "Inhibition of VEGFR-3 activation in tumor-draining lymph nodes suppresses the outgrowth of lymph node metastases in the MT-450 syngeneic rat breast cancer model." in: Clinical & experimental metastasis, Vol. 31, Issue 3, pp. 351-65, (2014) (PubMed).
: "The effect of podoplanin inhibition on lymphangiogenesis under pathological conditions." in: Investigative ophthalmology & visual science, Vol. 55, Issue 8, pp. 4813-22, (2014) (PubMed).
: "Cancer-associated fibroblasts expressing CXCL14 rely upon NOS1-derived nitric oxide signaling for their tumor-supporting properties." in: Cancer research, Vol. 74, Issue 11, pp. 2999-3010, (2014) (PubMed).
: "Rapamycin inhibition of CFA-induced lymphangiogenesis in PLN is independent of mast cells." in: Molecular biology reports, Vol. 41, Issue 4, pp. 2217-28, (2014) (PubMed).
: "Clonal analysis identifies hemogenic endothelium as the source of the blood-endothelial common lineage in the mouse embryo." in: Blood, Vol. 124, Issue 16, pp. 2523-32, (2014) (PubMed).
: "Lymphatic drainage pathways from the cervix uteri: implications for radical hysterectomy?" in: Gynecologic oncology, Vol. 132, Issue 1, pp. 107-13, (2014) (PubMed).
: "Steady-state antigen scavenging, cross-presentation, and CD8+ T cell priming: a new role for lymphatic endothelial cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 192, Issue 11, pp. 5002-11, (2014) (PubMed).
: "Apelin promotes lymphangiogenesis and lymph node metastasis." in: Oncotarget, Vol. 5, Issue 12, pp. 4426-37, (2014) (PubMed).
: "Tumor-derived interleukin-1 promotes lymphangiogenesis and lymph node metastasis through M2-type macrophages." in: PLoS ONE, Vol. 9, Issue 6, pp. e99568, (2014) (PubMed).
: "Optimization and regeneration kinetics of lymphatic-specific photodynamic therapy in the mouse dermis." in: Angiogenesis, Vol. 17, Issue 2, pp. 347-57, (2014) (PubMed).
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: "The lymphatic vascular system of the mouse head." in: Cell and tissue research, (2016) (PubMed).
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- LYVE1 (Lymphatic Vessel Endothelial Hyaluronan Receptor 1 (LYVE1))
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别名
- Lyve-1
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背景
- Lyve1, Xlkd1, Lyve-1, Crsbp-1, 1200012G08Rik,LYVE-1 has been identified as a major receptor for HA (extracellular matrix glycosaminoglycan hyaluronan) on the lymph vessel wall. The deduced amino acid sequence of LYVE-1 predicts a 322-residue type I integral membrane polypeptide 41 % similar to the CD44 HA receptor with a 212-residue extracellular domain containing a single Link module the prototypic HA binding domain of the Link protein superfamily. Like CD44, the LYVE-1 Molecule binds both soluble and immobilized HA. However, unlike CD44, the LYVE-1 Molecule colocalizes with HA on the luminal face of the lymph vessel wall and is completely absent from blood vessels. Hence, LYVE-1 is the first lymph-specific HA receptor to be characterized and is a uniquely powerful marker for lymph vessels themselves.
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基因ID
- 114332
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NCBI登录号
- NM_053247, NP_444477
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UniProt
- Q8BHC0
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途径
- Glycosaminoglycan Metabolic Process
抗原
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