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CEACAM1 抗体 (deltaN-Term)

CEACAM1 适用: 人 WB, FACS, ELISA 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN1589889
发货至: 中国
  • 抗原 See all CEACAM1 抗体
    CEACAM1 (Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 (CEACAM1))
    抗原表位
    • 7
    • 5
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    • 2
    • 2
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    deltaN-Term
    适用
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    宿主
    • 51
    • 37
    • 2
    克隆类型
    • 48
    • 42
    多克隆
    标记
    • 46
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    • 1
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    This CEACAM1 antibody is un-conjugated
    应用范围
    • 46
    • 34
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    • 15
    • 12
    • 9
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    • 5
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    Western Blotting (WB), Flow Cytometry (FACS), ELISA
    原理
    CEACAM-1 (dN) antibody
    特异性
    Recombinant human sCEA-1 (ΔN)
    产品特性
    Chromosomal location: 19q13.2
    Produced from sera of rabbits immunized with highly pure recombinant human soluble CEACAM-1 (ΔN) (Carcinoembryonic antigen-related cell adhesion molecule-1, SwissProt: #P13688) as the immunizing antigen.
    纯化方法
    Anti-human soluble CEACAM-1 was purified by affinity chromatography with immobilized Protein A.
    免疫原
    Recombinant human sCEA-1 (deltaN)
    亚型
    IgG
    Top Product
    Discover our top product CEACAM1 Primary Antibody
  • 应用备注
    Western Blot: Use 2-5 μg/mL
    限制
    仅限研究用
  • 状态
    Lyophilized
    溶解方式
    Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/mL.
    缓冲液
    PBS
    注意事项
    Centrifuge vial prior to opening.
    储存条件
    4 °C,-20 °C
    储存方法
    The lyophilized antibody is stable for at least 2 years at -20°C. After sterile reconstitution the antibody is stable at 2-8°C for up to 6 months. Frozen aliquots are stable for at least 6 months when stored at -20°C. Addition of a carrier protein or 50% glycerol is recommended for frozen aliquots.
    有效期
    24 months
  • 抗原
    CEACAM1 (Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 (CEACAM1))
    别名
    CEACAM-1 (CEACAM1 产品)
    背景
    CEACAM1, BGP, BGP1, BGPI, CD66a,Carcinoembryonic antigen (CEA)-related cell adhesion molecule 1 (CEACAM1, also BGP) is a 160 kDa member of the CEACAM branch of the CEA gene family of the immunoglobulin superfamily (1-3). It is one of seven human CEACAM subfamily genes that are essentially divided equally between type I trans-membrane proteins (CEACAM1, 3-4) and GPI-linked molecules (CEACAM5-8). There is no CEACAM2 in human. The gene for human CEACAM1 codes for a 526 amino acid (aa) type I transmembrane protein that contains a 34 aa signal sequence, a 394 aa extracellular domain (ECD), a 24 aa transmembrane segment, and a 74aa cytoplasmic region (4, 5). The ECD contains one N-terminal V-type followed by three C2-type Ig-like domains. It shows considerable glycosylation (1). The cytoplasmic region shows one ITIM motif and a calmodulin binding site (1-3). There are three soluble and seven transmembrane isoforms, with variations occurring in both the ECD and cytoplasmic region. All ten alternate splice forms contain the V-type Ig-like domain (aa's 35-142). The three soluble forms also contain the first two C2-type Ig like domains (aa's 145 317), with differences coming in the third C2-type Ig- like domain (6). The seven transmembrane isoforms are highly divergent. Full-length mouse and rat CEACAM1 are approximately 57 % aa identical to human CEACAM1, in the V-type Ig-like domain, they are 58 % and 56 % aa identical, respectively. The full-length molecule is found on neutrophils, bile duct epithelium, activated NK cells, colonic columnar epithelium and endothelium.
    基因ID
    634
    NCBI登录号
    NM_001205344, NP_001192273
    UniProt
    P13688
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