FLT4 抗体
Quick Overview for FLT4 抗体 (ABIN1589862)
抗原
See all FLT4 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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特异性
- Recombinant mouse soluble FLT-4
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产品特性
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Chromosomal location: 11 A5-B1, 11 25.0 cM
The hybridoma was generated after fusion with cells from rat immunized with purified, insect cell-derived recombinant mouse soluble FLT-4 (120 kDa) as the immunizing antigen. -
纯化方法
- Rat IgG1 antibody from hybridomas was purified from cell culture supernatant by Protein G chromatography.
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应用备注
- Western Blot: use 1-5 µg/mL.
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说明
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Monoclonal Antibody
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Reconstitute in sterile water to a concentration of 0.1-1.0 mg/mL.
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缓冲液
- PBS
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注意事项
- Centrifuge vial prior to opening.
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储存条件
- -20 °C
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储存方法
- The lyophilized antibody is stable at room temperature for up to 1 month. The reconstituted antibody is stable for at least two weeks at 2-8 °C. Frozen aliquots are stable for at least 6 months when stored at -20 °C.
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有效期
- 6 months
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Presence of lymphatics in a rat tendon lesion model." in: Histochemistry and cell biology, Vol. 143, Issue 4, pp. 411-9, (2015) (PubMed).
: "
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Presence of lymphatics in a rat tendon lesion model." in: Histochemistry and cell biology, Vol. 143, Issue 4, pp. 411-9, (2015) (PubMed).
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- FLT4 (Fms-Related Tyrosine Kinase 4 (FLT4))
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别名
- VEGFR-3/FLT-4
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背景
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VEGFR-3, also known as FLT4, is a member of the Tyr protein kinase family. The extracellular portion of VEGFR-3 contains 7 immunoglobulin (Ig)-like domains and the cytoplasmic portion contains a protein kinase domain. FLT4 regulates angiogenesis and lymphangiogenesis, its ligands are VEGF-C and D and its binding is mediated by the 2nd and 3rd Ig-like domains of FLT4. During fetal development VEGFR-3 is expressed on endothelial cells, however, in the adult mice, the vascular endothelial cells lose VEGFR-3 expression, but the lymphatic endothelium expresses it constitutively. In addition, VEGFR-3 expression can be induced in tumors with active angiogenesis.
Synonyms: vascular endothelial growth factor receptor-3, Flt4, Chy, Flt-4, VEGFR3, VEGFR-3, -
NCBI登录号
- NP_032055, NM_008029
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UniProt
- P35917
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途径
- RTK signaling, Signaling Events mediated by VEGFR1 and VEGFR2, VEGF Signaling
抗原
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