PDGFC 抗体
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- 抗原 See all PDGFC 抗体
- PDGFC (Platelet-Derived Growth Factor C (PDGFC))
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适用
- Parapoxvirus
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This PDGFC antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 特异性
- Recombinant ov-VEGF-E
- 产品特性
- Produced from sera of rabbits immunized with highly pure recombinant ov-VEGF-E produced in E. coli. A DNA sequence encoding the mature variant of ov-VEGF-E isolate D1701 (Dehio et al., 1999, GenBank accession No. AF106020) was expressed in E. coli as a 132 amino acid residue fusion protein with an N-terminal His-tag sequence and a thrombin cleavage site. Based on sequence similarity to VEGF-A, a gene encoding a VEGF homologue has recently been discovered in the genome of Orf virus (OV) (Lyttle et al., 1994). Different isolates of Orf virus show significant amino acid sequence similarity to VEGF-A and described as a viral virulence factor that appears to be derived from captured host genes. All eight Cysteine residues of the central Cysteine knot motif characteristic of members of the VEGF family are conserved among other residues in the VEGF-E proteins (Dehio et al., 1999, Wise et al., 1999). Alignment of all mammalian VEGF sequences indicated that VEGF-E is distinct from the previously described VEGFs but most closely related to VEGF-A. Like VEGF-A, VEGF-E was found to bind with high affinity to VEGF receptor-2 (KDR) resulting in receptor autophosphorylation, whilst in contrast to VEGF-A, VEGF-E cannot bind to VEGF receptor-1 (Flt-1). Furthermore VEGF-E can also not bind to VEGF receptor-3 (FLT-4). Therefore VEGF-E is a potent angiogenic factor selectively binding to VEGF receptor -2/KDR.
- 亚型
- IgG
- Top Product
- Discover our top product PDGFC Primary Antibody
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anti-Platelet-Derived Growth Factor C (PDGFC) (AA 61-110) antibody
PDGFC 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Platelet-Derived Growth Factor C (PDGFC) (AA 201-300) antibodyPDGFC 适用: 小鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Platelet-Derived Growth Factor C (PDGFC) (AA 235-345) antibodyPDGFC 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Platelet-Derived Growth Factor C (PDGFC) antibodyPDGFC 适用: 人, 小鼠, 大鼠 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Platelet-Derived Growth Factor C (PDGFC) (AA 236-345) antibodyPDGFC 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Platelet-Derived Growth Factor C (PDGFC) (AA 183-245) antibodyPDGFC 适用: 人 IHC (p), IF 宿主: 兔 Polyclonal unconjugated
anti-Platelet-Derived Growth Factor C (PDGFC) (AA 1-345) antibodyPDGFC 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Platelet-Derived Growth Factor C (PDGFC) (C-Term) antibodyPDGFC 适用: 人 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Platelet-Derived Growth Factor C (PDGFC) (AA 23-345) antibodyPDGFC 适用: 小鼠 WB, IHC, ICC 宿主: 兔 Polyclonal unconjugated
anti-Platelet-Derived Growth Factor C (PDGFC) (AA 74-103) antibodyPDGFC 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- Western Blot: use 1-5 µg/mL
- 说明
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Rabbit IG Polyclonal Antibody
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Reconstitute in sterile water to a concentration of 0.1-1.0 mg/mL.
- 缓冲液
- PBS
- 注意事项
- Centrifuge vial prior to opening.
- 储存条件
- -20 °C
- 储存方法
- The lyophilized antibody is stable at room temperature for up to 1 month. The reconstituted antibody is stable for at least two weeks at 2-8 °C. Frozen aliquots are stable for at least 6 months when stored at -20 °C.
- 有效期
- 6 months
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- 抗原
- PDGFC (Platelet-Derived Growth Factor C (PDGFC))
- 别名
- VEGF-E (PDGFC 产品)
- 别名
- SCDGF antibody, FALLOTEIN antibody, 1110064L01Rik antibody, AI647969 antibody, PDGF-C antibody, platelet derived growth factor C antibody, platelet-derived growth factor, C polypeptide antibody, PDGFC antibody, Pdgfc antibody
- 物质类
- Viral Protein
- 背景
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A DNA sequence encoding the mature variant of ov-VEGF-E isolate D1701 was expressed in E. coli as a 132 amino acid residue fusion protein with an N-terminal His-tag sequence and a thrombin cleavage site. Recombinant VEGF-E homodimer was dimerized in vitro and has a predicted mass of approximately 35 kDa. Based on sequence similarity to VEGF-A, a gene encoding a VEGF homologue has recently been discovered in the genome of Orf virus (OV). Different isolates of Orf virus show significant amino acid sequence similarity to VEGF-A and described as a viral virulence factor that appears to be derived from captured host genes. All eight Cysteine residues of the central Cysteine knot motif characteristic of members of the VEGF family are conserved among other residues in the VEGF-E proteins. Alignment of all mammalian VEGF sequences indicated that VEGF-E is distinct from the previously described VEGFs but most closely related to VEGF-A. Like VEGF-A, VEGF-E was found to bind with high affinity to VEGF receptor-2 (KDR) resulting in receptor autophosphorylation, whilst in contrast to VEGF-A, VEGF-E cannot bind to VEGF receptor-1 (Flt-1). Furthermore VEGF-E can also not bind to VEGF receptor-3 (FLT-4). Therefore VEGF-E is a potent angiogenic factor selectively binding to VEGF receptor –2/KDR.
Synonyms: VEGF-E - UniProt
- Q9YMF3
- 途径
- RTK signaling, Platelet-derived growth Factor Receptor Signaling
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