TIE1 抗体
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北京 101111
Quick Overview for TIE1 抗体 (ABIN1589693)
抗原
See all TIE1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- TIE-1 antibody
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特异性
- Recombinant human soluble TIE-2
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交叉反应 (详细)
- The monoclonal antibody will detect native human TIE-1 in ELISA experiments and on the surface of different human cell types. The antibody can be used for ELISA experiments and Western blotting.
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产品特性
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Chromosomal location: 1p34-p33
The monoclonal antibody was produced with the help of BALB/c mice using recombinant human soluble extracellular TIE-1 as the immunizing antigen. -
纯化方法
- Mouse IgG1 antibody (#6F12) from hybridomas was purified from cell culture supernatant by Protein G chromatography.
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免疫原
- Recombinant human soluble TIE-1
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亚型
- IgG1
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应用备注
- ELISA: Use at 1-15 μg/mL, Western blotting: Use at 1-2 μg/mL, FACS analysis and cell sorting: Test under progress.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/mL.
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缓冲液
- PBS
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注意事项
- Centrifuge vial prior to opening.
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储存条件
- 4 °C,-20 °C
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储存方法
- The lyophilized antibody is stable for at least 2 years at -20°C. After sterile reconstitution the antibody is stable at 2-8°C for up to 6 months. Frozen aliquots are stable for at least 6 months when stored at -20°C. Addition of a carrier protein or 50% glycerol is recommended for frozen aliquots.
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有效期
- 24 months
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- TIE1 (tyrosine Kinase with Immunoglobulin-Like and EGF-Like Domains 1 (TIE1))
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别名
- TIE-1
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背景
- TIE1, TIE, JTK14,Tie-1/Tie and Tie-2/Tek are receptor tyrosine kinases with unique structural characteristics including two immunoglobulin-like domains flanking three epidermal growth factor (EGF)-like domains, followed by three fibronectin type III-like repeats in the extracellular region, and a split tyrosine kinase domain in the cytoplasmic region. Tie-2 is a receptor for the angiopoietin (ANG) family: ANG-1, ANG-2, and ANG-3 (mouse)/-4 (human). It is involved in vascular stabilization and remodeling. Although less well understood, Tie-1 may also act as an ANG receptor, possibly in complex with Tie-2.
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基因ID
- 7075
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NCBI登录号
- NM_005424, NP_005415
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UniProt
- P35590
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途径
- RTK signaling
抗原
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