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HMGB1 抗体

This anti-HMGB1 antibody is a 小鼠 单克隆 antibody detecting HMGB1 in WB, IHC, IF 和 ICC. Suitable for 人, 小鼠, 大鼠, Cow, Pig 和 哺乳动物.
产品编号 ABIN1580427
发货至: 中国

Quick Overview for HMGB1 抗体 (ABIN1580427)

抗原

See all HMGB1 抗体
HMGB1 (High Mobility Group Box 1 (HMGB1))

适用

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人, 小鼠, 大鼠, Cow, Pig, 哺乳动物

宿主

  • 156
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小鼠

克隆类型

  • 144
  • 64
单克隆

标记

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This HMGB1 antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

克隆位点

1F3
  • 纯化方法

    affinity purified antibody

    亚型

    IgG2b
  • 应用备注

    The antibody solution can be used at dilutions of 1:1,000 or higher in immunofluorescence experiments. In western blotting using chemiluminescence it can be used at dilutions of 1:1,000-2,000.

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    1 mg/mL

    储存液

    Sodium azide

    注意事项

    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    注意事项

    Avoid repeated freezing and thawing.

    储存条件

    4 °C/-20 °C

    储存方法

    Store at 4°C short term or -20°C long term.
  • 抗原

    HMGB1 (High Mobility Group Box 1 (HMGB1))

    别名

    High mobility group box 1, Amphoterin, HMGB1

    背景

    High-mobility group proteins were named originally since they are abundant relatively low molecular weight proteins which run quickly on SDS-PAGE gels. High-mobility group proteis box 1 (HMGB1) is one of these. The bx in the name refers to the so-called high mobility group (HMG) box, a compact domain involved in DNA binding and protein-protein interactions. The HMGB1 molecule has two of these HMG domains. The protein is also called amphoterin, this name being derived from the presence of two highly charged regions in the molecule, a relatively neutrally charged N-terminus and a very negatively charged C-terminus. In fact, the molecule is very unusually charged throughout, the human sequence consisting of 16.7% Glutamic acid, 9.3% Aspartic acid, 20% Lysine and 9.3% Arginine. HMGB1 can bind Toll like receptor 4 (TLR4) and the Receptor for Advanced Glycation End products (RAGE). TLRs are components of the innate immune system, first recognized as a family of receptors which recognize Pathogen Associated Molecular Pattern molecules (PAMPs). PAMPs are common components of bacteria and when TLRs bind these, a strong inflammatory response is activated. More recently it has been recognized that TLRs can also be activated by Damage Associated Molecular Pattern molecules (DAMPs), which are endogenous substances released from damaged and diseased cells which also bind to TLR family receptors and also activate inflammation. HMGB1 is such a DAMP, binding to TLR4, and much evidence suggests that HMGB1 is a strong activator of inflammation. Interestingly, HMGB1 is released by necrotic cells but not by apoptotic cells. The HGNC name for this protein is HBGB1.

    途径

    p53 Pathway, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Toll-Like Receptors Cascades, Smooth Muscle Cell Migration, Inflammasome
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