TIE1 抗体
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北京 101111
Quick Overview for TIE1 抗体 (ABIN155171)
抗原
See all TIE1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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特异性
- This antibody will detect native TIE-1 in ELISA experiments and on the surface of different cell types.
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纯化方法
- Protein G chromatography
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免疫原
- Recombinant human soluble TIE-1 protein
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亚型
- IgG1
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anti-tyrosine Kinase with Immunoglobulin-Like and EGF-Like Domains 1 (TIE1) (AA 385-607) antibody
TIE1 适用: 人 ELISA, IHC 宿主: 小鼠 Monoclonal 8D12D2 unconjugated
anti-tyrosine Kinase with Immunoglobulin-Like and EGF-Like Domains 1 (TIE1) (AA 385-607) antibodyTIE1 适用: 人 WB, ELISA, IHC 宿主: 小鼠 Monoclonal 8D12B10 unconjugated
anti-tyrosine Kinase with Immunoglobulin-Like and EGF-Like Domains 1 (TIE1) (AA 435-609) antibodyTIE1 适用: 人 WB, ELISA, ICC, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-tyrosine Kinase with Immunoglobulin-Like and EGF-Like Domains 1 (TIE1) (AA 701-898) antibodyTIE1 适用: 人 WB, ELISA, ICC, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-tyrosine Kinase with Immunoglobulin-Like and EGF-Like Domains 1 (TIE1) (AA 701-898) antibodyTIE1 适用: 人 WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal C2 unconjugated
anti-tyrosine Kinase with Immunoglobulin-Like and EGF-Like Domains 1 (TIE1) (AA 217-328) antibodyTIE1 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-tyrosine Kinase with Immunoglobulin-Like and EGF-Like Domains 1 (TIE1) antibodyTIE1 适用: 人 WB, FACS 宿主: 小鼠 Monoclonal 25GB725 unconjugated
anti-tyrosine Kinase with Immunoglobulin-Like and EGF-Like Domains 1 (TIE1) (AA 536-643) antibodyTIE1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3E9 unconjugated
anti-tyrosine Kinase with Immunoglobulin-Like and EGF-Like Domains 1 (TIE1) antibodyTIE1 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-tyrosine Kinase with Immunoglobulin-Like and EGF-Like Domains 1 (TIE1) (AA 361-389) antibodyTIE1 适用: 人, 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
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ELISA: 1-15 μg/mL. Western blot: 1-2 μg/mL. FACS. Cell sorting.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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溶解方式
- Restore in sterile water to a concentration of 1.0 mg/mL.
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缓冲液
- PBS, pH 7.4 without preservatives or stabilizers
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储存液
- Without preservative
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注意事项
- This product is photosensitive and should be protected from light
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储存条件
- 4 °C
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储存方法
- Store the antibody undiluted Prior to and After reconstitution at 2-8 °C. DO NOT FREEZE!
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- TIE1 (tyrosine Kinase with Immunoglobulin-Like and EGF-Like Domains 1 (TIE1))
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别名
- TIE1
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背景
- TIE1/TIE (tyrosine kinase with Ig and EGF homology domains 1) and TIE2/Tek define a new class of the receptor tyrosine kinase (RTK) subfamily with unique structural characteristics: two immunoglobulin like domains flanking three epidermal growth factor (EFG) like domains followed by three fibronectin type III like repeats in the extracellular region and a split tyrosine kinase domain in the cytoplasmic region. Human TIE1 cDNA encodes a 1138 amino acid residue precursor protein with a putative signal peptide, an extracellular domain, and a cytoplasmic domain. Human TIE1/Fc, a disulfide linked homodimeric protein, has a calculated molecular mass of approximately 107 kDa. Due to glycosylation, the protein migrates to approximately 160 kDa in SDS PAGE under reducing conditions. TIE1 and TIE2, expressed primarily on endothelial and hematopoietic progenitor cells, play important roles in angiogenesis, vasculogenesis, and hematopoiesis. In developing vascular endothelial cells, TIE1 and TIE2 are specifically expressed. Two ligands that bind TIE have been identified, angiopoietin 1 and angiopoietin 2. Based on gene targeting studies, the in vivo functions of TIE1 are related to endothelial cell differentiation. The receptor tyrosine kinase TIE also plays a role in the survival and integrity of the endothelium.Synonyms: TIE, Tie-1, Tyrosine-protein kinase receptor Tie-1
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基因ID
- 7075
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NCBI登录号
- NP_005415
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UniProt
- P35590
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途径
- RTK signaling
抗原
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