HMOX1 抗体 (N-Term)
Our Local Distributor
北京 101111
Quick Overview for HMOX1 抗体 (N-Term) (ABIN155124)
抗原
See all HMOX1 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- N-Term
-
特异性
- The antibody recognizes ~32 kDa Heme-Oxygenase-1.
-
纯化方法
- Affinity Chromatography
-
免疫原
- Synthetic peptide surrounding amino acid near the N-terminus of Human HO-1
-
-
-
-
应用备注
-
Western Blot: 0.5-2 μg/mL. Immunoprecipitation: 10-20 μg/mL. Immunohistochemistry: 10-20 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
-
-
-
浓度
- 0.5 mg/mL
-
缓冲液
- PBS, 0.5 % BSA, 30 % Glycerol, 0.01 % Thimerosal
-
储存液
- Sodium azide, Thimerosal (Merthiolate)
-
注意事项
- This product contains Sodium azide and Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
-
注意事项
- Avoid repeated freezing and thawing.
-
储存条件
- -20 °C/-80 °C
-
储存方法
- Store the antibody undiluted at -20 °C or for long term storage (in aliquots) at -70 °C.
-
-
- HMOX1 (Heme Oxygenase (Decycling) 1 (HMOX1))
-
别名
- Heme Oxygenase 1 / HMOX1
-
背景
- Heme oxygenase-1 (HO-1) or HSP32 is the inducible isoform of heme oxygenase which catalyzes the NADPH, O2 and cytochrome P450 reductase dependent oxidation of heme to carbon monoxide, iron and biliverdin that is immediately reduced to bilirubin. To date, three heme oxygenase isoforms HO-1, HO-2 and HO-3 have been identified. HO-1, also known as Hsp32, a major heat shock/stress response protein, is ubiquitous and its mRNA as well as its activity can be increased several-fold by heme, other metalloporphyrins, transition metals and stimuli that induce cellular stress. The 5'-untranslated region (UTR) of HO-1 has several consensus regulatory elements that include sites for activator protein 1 (AP-1), metal responsive element (MRE), oncogene c-myc/max heterodimer binding site (Myc/Max), antioxidant response element (ARE) and GC box binding (Sp1). HO-1 expression has been shown to increase in benign postatic hyperplasia (BPH) and malignant prostate tissue suggesting a role for this stress protein in the pathogenesis of BPH and prostate cancer.Synonyms: HO, HO-1, HO1
-
基因ID
- 3162
-
NCBI登录号
- NP_002124
-
UniProt
- P09601
-
途径
- Transition Metal Ion Homeostasis, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, SARS-CoV-2 Protein Interactome
抗原
-