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XAF1 抗体 (AA 166-194)

This anti-XAF1 antibody (ABIN1537930) is a Rabbit Polyclonal antibody detecting XAF1 in WB. Suitable for Mouse.
产品编号 ABIN1537930
发货至: 中国

Quick Overview for XAF1 抗体 (AA 166-194) (ABIN1537930)

抗原

See all XAF1 抗体
XAF1 (XiAP Associated Factor 1 (XAF1))

适用

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  • 13
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小鼠

宿主

  • 35
  • 11

克隆类型

  • 37
  • 9
多克隆

标记

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This XAF1 antibody is un-conjugated

应用范围

  • 26
  • 16
  • 7
  • 7
  • 6
  • 2
  • 1
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Western Blotting (WB)

克隆位点

RB40264
  • 抗原表位

    • 6
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    • 1
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    AA 166-194

    纯化方法

    This antibody is purified through a protein A column, followed by peptide affinity purification.

    免疫原

    This Mouse Xaf1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 166-194 amino acids from the Central region of mouse Xaf1.

    亚型

    Ig Fraction
  • 应用备注

    WB: 1:1000

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C,-20 °C

    储存方法

    Mouse Xaf1 Antibody (Center) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, keep at -20 °C.

    有效期

    6 months
  • 抗原

    XAF1 (XiAP Associated Factor 1 (XAF1))

    别名

    Xaf1

    背景

    Xaf1 seems to function as a negative regulator of members of the IAP (inhibitor of apoptosis protein) family. Inhibits anti-caspase activity of BIRC4. Induces cleavage and inactivation of BIRC4 independent of caspase activation. Mediates TNF-alpha-induced apoptosis and is involved in apoptosis in trophoblast cells. May inhibit BIRC4 indirectly by activating the mitochondrial apoptosis pathway. After translocation to mitochondra, promotes translocation of BAX to mitochondria and cytochrome c release from mitochondria. Seems to promote the redistribution of BIRC4 from the cytoplasm to the nucleus, probably independent of BIRC4 inactivation which seems to occur in the cytoplasm. The BIRC4-XAF1 complex mediates down-regulation of BIRC5/survivin, the process requires the E3 ligase activity of BIRC4. Seems to be involved in cellular sensitivity to the proapoptotic actions of TRAIL. May be a tumor suppressor by mediating apoptosis resistance of cancer cells (By similarity).

    分子量

    31117

    基因ID

    327959

    NCBI登录号

    NP_001032802

    UniProt

    Q5NBU8
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