GPR109B 抗体 (AA 285-334)
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北京 101111
Quick Overview for GPR109B 抗体 (AA 285-334) (ABIN1535621)
抗原
See all GPR109B (HCAR3) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 285-334
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原理
- HM74 Antibody
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特异性
- HM74 Polyclonal Antibody detects endogenous levels of HM74 protein.
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纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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纯度
- > 95 %
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免疫原
- The antiserum was produced against synthesized peptide derived from human GPR109. AA range:285-334
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亚型
- IgG
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anti-Hydroxycarboxylic Acid Receptor 3 (HCAR3) antibody
HCAR3 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Hydroxycarboxylic Acid Receptor 3 (HCAR3) (Cytoplasmic Domain) antibodyHCAR3 适用: 人, 犬, Hamster IHC, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-Hydroxycarboxylic Acid Receptor 3 (HCAR3) (AA 285-334) antibodyHCAR3 适用: 人, 小鼠, 大鼠 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Hydroxycarboxylic Acid Receptor 3 (HCAR3) (AA 71-99), (N-Term) antibodyHCAR3 适用: 人 WB 宿主: 兔 Polyclonal RB30531 unconjugated
anti-Hydroxycarboxylic Acid Receptor 3 (HCAR3) (AA 1-387) antibodyHCAR3 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Hydroxycarboxylic Acid Receptor 3 (HCAR3) (C-Term) antibodyHCAR3 适用: 人, 小鼠, 大鼠 WB, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C/1 year
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有效期
- 12 months
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- GPR109B (HCAR3) (Hydroxycarboxylic Acid Receptor 3 (HCAR3))
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别名
- GPR109
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背景
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Synonyms: HCAR3, GPR109B, HCA3, HM74B, NIACR2, Hydroxycarboxylic acid receptor 3, G-protein coupled receptor 109B, G-protein coupled receptor HM74, G-protein coupled receptor HM74B, Niacin receptor 2, Nicotinic acid receptor 2, HCAR2, GPR109A, HCA2, Hydroxycarboxylic acid receptor 2,
Background: developmental stage:Expression in neutrophils occurs in the late terminal differentiation phase.,function:Acts as a high affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i)-protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Mediates nicotinic acid-induced apoptosis in mature neutrophils. Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and phosphorylation of target proteins, leading to neutrophil apoptosis.,miscellaneous:The rank order of potency for the displacement of nicotinic acid binding is 5-methyl pyrazole-3-carboxylic acid = pyridine-3-acetic acid > acifran > 5-methyl nicotinic acid = acipimox >> nicotinuric acid = nicotinamide.,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Expression largely restricted to adipose tissue and spleen. Expressed on mature neutrophils but not on immature neutrophils or eosinophils.,
Gene Name: HCAR2/HCAR3
Protein Name: HM74A/HM74B
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分子量
- 44 kDa
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基因ID
- 8843, 338442
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OMIM
- 606039
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UniProt
- P49019
抗原
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