MYSM1 抗体 (AA 520-569)
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北京 101111
Quick Overview for MYSM1 抗体 (AA 520-569) (ABIN1535215)
抗原
See all MYSM1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 520-569
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原理
- MYSM1 Antibody
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特异性
- MYSM1 Polyclonal Antibody detects endogenous levels of MYSM1 protein.
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纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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纯度
- > 95 %
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免疫原
- The antiserum was produced against synthesized peptide derived from human MYSM1. AA range:520-569
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亚型
- IgG
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anti-Myb-Like, SWIRM and MPN Domains 1 (MYSM1) (Internal Region) antibody
MYSM1 适用: 人, 小鼠, 大鼠 WB, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Myb-Like, SWIRM and MPN Domains 1 (MYSM1) antibodyMYSM1 适用: 人, 小鼠 ELISA, WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Myb-Like, SWIRM and MPN Domains 1 (MYSM1) (AA 118-147), (N-Term) antibodyMYSM1 适用: 人, 小鼠 WB, FACS, EIA 宿主: 兔 Polyclonal unconjugated
anti-Myb-Like, SWIRM and MPN Domains 1 (MYSM1) (AA 111-139), (N-Term) antibodyMYSM1 适用: 人, 小鼠 WB, FACS 宿主: 兔 Polyclonal RB27661 unconjugated
anti-Myb-Like, SWIRM and MPN Domains 1 (MYSM1) (AA 170-311) antibodyMYSM1 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Myb-Like, SWIRM and MPN Domains 1 (MYSM1) (AA 145-194) antibodyMYSM1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C/1 year
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有效期
- 12 months
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- MYSM1 (Myb-Like, SWIRM and MPN Domains 1 (MYSM1))
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别名
- MYSM1
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背景
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Synonyms: MYSM1, KIAA1915, Histone H2A deubiquitinase MYSM1, 2A-DUB, Myb-like, SWIRM and MPN domain-containing protein 1
Background: catalytic activity:Ubiquitin C-terminal thioester + H(2)O = ubiquitin + a thiol.,domain:Binds double-stranded DNA via the SANT domain. The SWIRM domain does not bind double-stranded DNA.,function:Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. Acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR)-induced gene activation.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the peptidase M67A family. MYSM1 subfamily.,similarity:Contains 1 MPN (JAB/Mov34) domain.,similarity:Contains 1 SANT domain.,similarity:Contains 1 SWIRM domain.,subunit:Component of a large chromatin remodeling complex, at least composed of MYSM1, PCAF, RBM10 and KIF11/TRIP5. Binds histones.,
Gene Name: MYSM1
Protein Name: Histone H2A deubiquitinase MYSM1
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分子量
- 95 kDa
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基因ID
- 114803
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UniProt
- Q5VVJ2
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途径
- Chromatin Binding
抗原
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