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SIAH1 抗体 (AA 181-230)

The 兔 多克隆 anti-SIAH1 antibody (ABIN1533986) specifically detects SIAH1 in WB, IHC, ELISA 和 IF. The antibody is reactive with 人, 大鼠 和 小鼠 samples.
产品编号 ABIN1533986
发货至: 中国
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Quick Overview for SIAH1 抗体 (AA 181-230) (ABIN1533986)

抗原

See all SIAH1 抗体
SIAH1 (E3 Ubiquitin-Protein Ligase SIAH1 (SIAH1))

适用

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人, 大鼠, 小鼠

宿主

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兔

克隆类型

  • 67
  • 2
多克隆

标记

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This SIAH1 antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)
  • 抗原表位

    • 15
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    • 7
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    AA 181-230

    原理

    Siah-1/2 Antibody

    特异性

    Siah-1/2 Polyclonal Antibody detects endogenous levels of Siah-1/2 protein.

    纯化方法

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

    纯度

    > 95 %

    免疫原

    The antiserum was produced against synthesized peptide derived from human SIAH1. AA range:181-230

    亚型

    IgG
  • 应用备注

    WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    1 mg/mL

    缓冲液

    Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    Store at -20°C/1 year

    有效期

    12 months
  • 抗原

    SIAH1 (E3 Ubiquitin-Protein Ligase SIAH1 (SIAH1))

    别名

    SIAH1

    背景

    Synonyms: SIAH1; HUMSIAH; E3 ubiquitin-protein ligase SIAH1; Seven in absentia homolog 1; Siah-1; Siah-1a; SIAH2; E3 ubiquitin-protein ligase SIAH2; Seven in absentia homolog 2; Siah-2; hSiah2

    Background: This gene encodes a protein that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in the development of certain forms of Parkinson's disease, the regulation of the cellular response to hypoxia and induction of apoptosis. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008],

    Gene Name: SIAH1/SIAH2

    Protein Name: E3 ubiquitin-protein ligase SIAH1/2

    分子量

    31 kDa

    基因ID

    6477, 6478

    OMIM

    602212

    UniProt

    Q8IUQ4
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