DOK3 抗体 (AA 101-150)
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北京 101111
Quick Overview for DOK3 抗体 (AA 101-150) (ABIN1533971)
抗原
See all DOK3 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 101-150
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原理
- Dok-3 Antibody
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特异性
- Dok-3 Polyclonal Antibody detects endogenous levels of Dok-3 protein.
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纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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纯度
- > 95 %
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免疫原
- The antiserum was produced against synthesized peptide derived from human DOK3. AA range:101-150
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亚型
- IgG
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anti-Docking Protein 3 (DOK3) (AA 128-385) antibody
DOK3 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Docking Protein 3 (DOK3) (C-Term) antibodyVerified DOK3 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Docking Protein 3 (DOK3) (AA 1-146) antibodyDOK3 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Docking Protein 3 (DOK3) (Internal Region) antibodyDOK3 适用: 人, 小鼠, 大鼠 WB, IHC, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Docking Protein 3 (DOK3) antibodyDOK3 适用: 人 WB, FACS 宿主: 小鼠 Monoclonal 24GB8365 unconjugated
anti-Docking Protein 3 (DOK3) antibodyDOK3 适用: 人 WB, FACS 宿主: 小鼠 Monoclonal 24GB8360 unconjugated
anti-Docking Protein 3 (DOK3) (AA 293-321), (C-Term) antibodyDOK3 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB31947 unconjugated
anti-Docking Protein 3 (DOK3) (AA 1-330) antibodyDOK3 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Docking Protein 3 (DOK3) (AA 45-310) antibodyDOK3 适用: 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Docking Protein 3 (DOK3) antibodyDOK3 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C/1 year
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有效期
- 12 months
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- DOK3 (Docking Protein 3 (DOK3))
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别名
- DOK3
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背景
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Synonyms: DOK3, Docking protein 3, Downstream of tyrosine kinase 3
Background: domain:PTB domain mediates receptor interaction.,function:DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK3 is a negative regulator of JNK signaling in B-cells through interaction with INPP5D/SHIP1. May modulate ABL function.,PTM:Constitutively tyrosine-phosphorylated.,PTM:On IL2 stimulation, phosphorylated on C-terminal tyrosine residues possibly by Src kinases. Can also be phosphorylated by ABL kinase.,similarity:Belongs to the DOK family. Type A subfamily.,similarity:Contains 1 IRS-type PTB domain.,similarity:Contains 1 PH domain.,subunit:On tyrosine phosphorylation, interacts with CSK and INPP5D/SHIP1 via their SH2 domains. Both Tyr-381 and Tyr-398 are required for interaction with INPP5D. Only Tyr-381 is required for interaction with CSK. Binds ABL through the PTB domain and in a kinase-dependent manner. Does not interact with RasGAP.,tissue specificity:Expressed in spleen.,
Gene Name: DOK3
Protein Name: Docking protein 3
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分子量
- 53 kDa
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基因ID
- 79930
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OMIM
- 611435
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UniProt
- Q7L591
抗原
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