KSR2 抗体 (AA 671-720)
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北京 101111
Quick Overview for KSR2 抗体 (AA 671-720) (ABIN1533965)
抗原
See all KSR2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 671-720
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原理
- Ksr2 Antibody
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特异性
- Ksr2 Polyclonal Antibody detects endogenous levels of Ksr2 protein.
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纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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纯度
- > 95 %
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免疫原
- The antiserum was produced against synthesized peptide derived from human KSR2. AA range:671-720
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亚型
- IgG
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应用备注
- WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:40000. Not yet tested in other applications.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C/1 year
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有效期
- 12 months
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- KSR2 (Kinase Suppressor of Ras 2 (KSR2))
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别名
- KSR2
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背景
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Synonyms: KSR2, Kinase suppressor of Ras 2, hKSR2
Background: domain:The protein kinase domain is predicted to be catalytically inactive.,function:Location-regulated scaffold connecting MEK to RAF. Blocks MAP3K8 kinase activity and MAP3K8-mediated signaling. Acts as a negative regulator of MAP3K3-mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production.,PTM:Phosphorylated on Ser-474 by MARK3.,similarity:Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.,similarity:Contains 1 phorbol-ester/DAG-type zinc finger.,similarity:Contains 1 protein kinase domain.,subunit:Interacts with MAP2K1, MAP3K8, MAPK, RAS and RAF.,tissue specificity:Mainly expressed in brain and kidney.,
Gene Name: KSR2
Protein Name: Kinase suppressor of Ras 2
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分子量
- 107 kDa
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基因ID
- 283455
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OMIM
- 610737
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UniProt
- Q6VAB6
抗原
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