ERCC5 抗体 (AA 131-180)
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北京 101111
Quick Overview for ERCC5 抗体 (AA 131-180) (ABIN1533685)
抗原
See all ERCC5 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 131-180
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原理
- XPG Antibody
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特异性
- XPG Polyclonal Antibody detects endogenous levels of XPG protein.
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纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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纯度
- > 95 %
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免疫原
- The antiserum was produced against synthesized peptide derived from human ERCC5. AA range:131-180
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亚型
- IgG
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应用备注
- WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:5000. Not yet tested in other applications.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C/1 year
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有效期
- 12 months
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- ERCC5 (DNA Repair Protein Complementing XP-G Cells (ERCC5))
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别名
- ERCC5
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背景
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Synonyms: ERCC5; ERCM2; XPG; XPGC; DNA repair protein complementing XP-G cells; DNA excision repair protein ERCC-5; Xeroderma pigmentosum group G-complementing protein
Background: This gene encodes a single-strand specific DNA endonuclease that makes the 3' incision in DNA excision repair following UV-induced damage. The protein may also function in other cellular processes, including RNA polymerase II transcription, and transcription-coupled DNA repair. Mutations in this gene cause xeroderma pigmentosum complementation group G (XP-G), which is also referred to as xeroderma pigmentosum VII (XP7), a skin disorder characterized by hypersensitivity to UV light and increased susceptibility for skin cancer development following UV exposure. Some patients also develop Cockayne syndrome, which is characterized by severe growth defects, mental retardation, and cachexia. Read-through transcription exists between this gene and the neighboring upstream BIVM (basic, immunoglobulin-like variable motif containing) gene. [provided by RefSeq, Feb 2011],
Gene Name: ERCC5
Protein Name: DNA repair protein complementing XP-G cells
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分子量
- 133 kDa
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基因ID
- 2073
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OMIM
- 133520
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UniProt
- P28715
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途径
- DNA Damage Repair
抗原
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