TOP3B 抗体 (AA 51-100)
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北京 101111
Quick Overview for TOP3B 抗体 (AA 51-100) (ABIN1533574)
抗原
See all TOP3B 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 51-100
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原理
- Topo IIIβ-1 Antibody
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特异性
- Topo IIIβ-1 Polyclonal Antibody detects endogenous levels of Topo IIIβ-1 protein.
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纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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纯度
- > 95 %
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免疫原
- The antiserum was produced against synthesized peptide derived from human TOP3B. AA range:51-100
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亚型
- IgG
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应用备注
- WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C/1 year
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有效期
- 12 months
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- TOP3B (Topoisomerase (DNA) III beta (TOP3B))
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别名
- TOP3B
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背景
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Synonyms: TOP3B, TOP3B1, DNA topoisomerase 3-beta-1, DNA topoisomerase III beta-1
Background: This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus relaxing the supercoils and altering the topology of DNA. The enzyme interacts with DNA helicase SGS1 and plays a role in DNA recombination, cellular aging and maintenance of genome stability. Low expression of this gene may be related to higher survival rates in breast cancer patients. This gene has a pseudogene on chromosome 22. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Aug 2013],
Gene Name: TOP3B
Protein Name: DNA topoisomerase 3-beta-1
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分子量
- 96 kDa
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基因ID
- 8940
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OMIM
- 603582
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UniProt
- O95985
抗原
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