Dynamitin 抗体 (AA 341-390)
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Quick Overview for Dynamitin 抗体 (AA 341-390) (ABIN1533369)
抗原
See all Dynamitin (DCTN2) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 341-390
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原理
- Dynactin 2 Antibody
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特异性
- Dynactin 2 Polyclonal Antibody detects endogenous levels of Dynactin 2 protein.
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纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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纯度
- > 95 %
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免疫原
- The antiserum was produced against synthesized peptide derived from human p50 Dynamitin. AA range:341-390
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亚型
- IgG
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应用备注
- WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C/1 year
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有效期
- 12 months
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- Dynamitin (DCTN2) (Dynactin 2 (p50) (DCTN2))
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别名
- p50 Dynamitin
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背景
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Synonyms: DCTN2, DCTN50, Dynactin subunit 2, 50 kDa dynein-associated polypeptide, Dynactin complex 50 kDa subunit, DCTN-50, p50 dynamitin
Background: This gene encodes a 50-kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 4-5 copies per dynactin molecule. It contains three short alpha-helical coiled-coil domains that may mediate association with self or other dynactin subunits. It may interact directly with the largest subunit (p150) of dynactin and may affix p150 in place. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2012],
Gene Name: DCTN2
Protein Name: Dynactin subunit 2
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分子量
- 44 kDa
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基因ID
- 10540
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OMIM
- 138972
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UniProt
- Q13561
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途径
- M Phase, Ribonucleoprotein Complex Subunit Organization
抗原
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