ERCC1 抗体 (AA 141-190)
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北京 101111
Quick Overview for ERCC1 抗体 (AA 141-190) (ABIN1533265)
抗原
See all ERCC1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 141-190
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原理
- ERCC1 Antibody
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特异性
- ERCC1 Polyclonal Antibody detects endogenous levels of ERCC1 protein.
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纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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纯度
- > 95 %
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免疫原
- The antiserum was produced against synthesized peptide derived from human ERCC1. AA range:141-190
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亚型
- IgG
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应用备注
- WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C/1 year
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有效期
- 12 months
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- ERCC1 (Excision Repair Cross Complementing Polypeptide-1 (ERCC1))
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别名
- ERCC1
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背景
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Synonyms: ERCC1; DNA excision repair protein ERCC-1
Background: The product of this gene functions in the nucleotide excision repair pathway, and is required for the repair of DNA lesions such as those induced by UV light or formed by electrophilic compounds including cisplatin. The encoded protein forms a heterodimer with the XPF endonuclease (also known as ERCC4), and the heterodimeric endonuclease catalyzes the 5' incision in the process of excising the DNA lesion. The heterodimeric endonuclease is also involved in recombinational DNA repair and in the repair of inter-strand crosslinks. Mutations in this gene result in cerebrooculofacioskeletal syndrome, and polymorphisms that alter expression of this gene may play a role in carcinogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. The last exon of this gene overlaps with the CD3e molecule, epsilon associated protein ge
Gene Name: ERCC1
Protein Name: DNA excision repair protein ERCC-1
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分子量
- 32 kDa
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基因ID
- 2067
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OMIM
- 126380
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UniProt
- P07992
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途径
- DNA Damage Repair, Production of Molecular Mediator of Immune Response
抗原
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