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ERCC1 抗体 (AA 141-190)

The 兔 多克隆 anti-ERCC1 antibody (ABIN1533265) specifically detects ERCC1 in WB, ELISA, IHC 和 IF. The antibody is reactive with 人 和 小鼠 samples.
产品编号 ABIN1533265
发货至: 中国
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Room 801-803
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Tel +86 (0512) 65829739 传真 +86 (010) 6788 5057

Quick Overview for ERCC1 抗体 (AA 141-190) (ABIN1533265)

抗原

See all ERCC1 抗体
ERCC1 (Excision Repair Cross Complementing Polypeptide-1 (ERCC1))

适用

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人, 小鼠

宿主

  • 108
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兔

克隆类型

  • 85
  • 84
多克隆

标记

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This ERCC1 antibody is un-conjugated

应用范围

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Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)
  • 抗原表位

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    AA 141-190

    原理

    ERCC1 Antibody

    特异性

    ERCC1 Polyclonal Antibody detects endogenous levels of ERCC1 protein.

    纯化方法

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

    纯度

    > 95 %

    免疫原

    The antiserum was produced against synthesized peptide derived from human ERCC1. AA range:141-190

    亚型

    IgG
  • 应用备注

    WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    1 mg/mL

    缓冲液

    Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    Store at -20°C/1 year

    有效期

    12 months
  • 抗原

    ERCC1 (Excision Repair Cross Complementing Polypeptide-1 (ERCC1))

    别名

    ERCC1

    背景

    Synonyms: ERCC1; DNA excision repair protein ERCC-1

    Background: The product of this gene functions in the nucleotide excision repair pathway, and is required for the repair of DNA lesions such as those induced by UV light or formed by electrophilic compounds including cisplatin. The encoded protein forms a heterodimer with the XPF endonuclease (also known as ERCC4), and the heterodimeric endonuclease catalyzes the 5' incision in the process of excising the DNA lesion. The heterodimeric endonuclease is also involved in recombinational DNA repair and in the repair of inter-strand crosslinks. Mutations in this gene result in cerebrooculofacioskeletal syndrome, and polymorphisms that alter expression of this gene may play a role in carcinogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. The last exon of this gene overlaps with the CD3e molecule, epsilon associated protein ge

    Gene Name: ERCC1

    Protein Name: DNA excision repair protein ERCC-1

    分子量

    32 kDa

    基因ID

    2067

    OMIM

    126380

    UniProt

    P07992

    途径

    DNA Damage Repair, Production of Molecular Mediator of Immune Response
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