Dysferlin 抗体 (AA 1981-2030)
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Quick Overview for Dysferlin 抗体 (AA 1981-2030) (ABIN1533258)
抗原
See all Dysferlin (DYSF) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1981-2030
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原理
- Dysferlin Antibody
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特异性
- Dysferlin Polyclonal Antibody detects endogenous levels of Dysferlin protein.
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纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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纯度
- > 95 %
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免疫原
- The antiserum was produced against synthesized peptide derived from human Dysferlin. AA range:1981-2030
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亚型
- IgG
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应用备注
- WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C/1 year
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有效期
- 12 months
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- Dysferlin (DYSF)
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别名
- Dysferlin
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背景
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Synonyms: DYSF, FER1L1, Dysferlin, Dystrophy-associated fer-1-like protein, Fer-1-like protein 1
Background: dysferlin(DYSF) Homo sapiens The protein encoded by this gene belongs to the ferlin family and is a skeletal muscle protein found associated with the sarcolemma. It is involved in muscle contraction and contains C2 domains that play a role in calcium-mediated membrane fusion events, suggesting that it may be involved in membrane regeneration and repair. In addition,The protein encoded by this gene binds caveolin-3, a skeletal muscle membrane protein which is important in the formation of caveolae. Specific mutations in this gene have been shown to cause autosomal recessive limb girdle muscular dystrophy type 2B (LGMD2B) as well as Miyoshi myopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2008],
Gene Name: DYSF
Protein Name: Dysferlin
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分子量
- 237 kDa
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基因ID
- 8291
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OMIM
- 253601
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UniProt
- O75923
抗原
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