EIF2AK2 抗体 (AA 413-462)
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Quick Overview for EIF2AK2 抗体 (AA 413-462) (ABIN1532984)
抗原
See all EIF2AK2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 413-462
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原理
- PKR Antibody
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特异性
- PKR Polyclonal Antibody detects endogenous levels of PKR protein.
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纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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纯度
- > 95 %
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免疫原
- The antiserum was produced against synthesized peptide derived from human PKR. AA range:413-462
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亚型
- IgG
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应用备注
- WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C/1 year
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有效期
- 12 months
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- EIF2AK2 (Eukaryotic Translation Initiation Factor 2-alpha Kinase 2 (EIF2AK2))
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别名
- PKR
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背景
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Synonyms: EIF2AK2, PKR, PRKR, Interferon-induced, double-stranded RNA-activated protein kinase, Eukaryotic translation initiation factor 2-alpha kinase 2, eIF-2A protein kinase 2, Interferon-inducible RNA-dependent protein kinase, P1/eIF-2A protein k
Background: The protein encoded by this gene is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate translation initiation factor EIF2S1, which in turn inhibits protein synthesis. This protein is also activated by manganese ions and heparin. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2011],
Gene Name: EIF2AK2
Protein Name: Interferon-induced double-stranded RNA-activated protein kinase
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分子量
- 62 kDa
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基因ID
- 5610
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OMIM
- 176871
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UniProt
- P19525
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途径
- DNA Damage Repair, ER-Nucleus Signaling, Hepatitis C
抗原
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