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BACE1 抗体 (AA 452-501)

The 兔 多克隆 anti-BACE1 antibody (ABIN1532227) specifically detects BACE1 in IHC, ELISA 和 IF. The antibody is reactive with 人, 小鼠 和 大鼠 samples.
产品编号 ABIN1532227
发货至: 中国
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Quick Overview for BACE1 抗体 (AA 452-501) (ABIN1532227)

抗原

See all BACE1 抗体
BACE1 (Beta-secretase 1 (BACE1))

适用

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人, 小鼠, 大鼠

宿主

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兔

克隆类型

  • 88
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多克隆

标记

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This BACE1 antibody is un-conjugated

应用范围

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Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)
  • 抗原表位

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    AA 452-501

    原理

    BACE Antibody

    特异性

    BACE Polyclonal Antibody detects endogenous levels of BACE protein.

    纯化方法

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

    纯度

    > 95 %

    免疫原

    The antiserum was produced against synthesized peptide derived from human BACE. AA range:452-501

    亚型

    IgG
  • 应用备注

    IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:5000. Not yet tested in other applications.

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    1 mg/mL

    缓冲液

    Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    Store at -20°C/1 year

    有效期

    12 months
  • 抗原

    BACE1 (Beta-secretase 1 (BACE1))

    别名

    BACE

    背景

    Synonyms: BACE1; BACE; KIAA1149; Beta-secretase 1; Aspartyl protease 2; ASP2; Asp 2; Beta-site amyloid precursor protein cleaving enzyme 1; Beta-site APP cleaving enzyme 1; Memapsin-2; Membrane-associated aspartic protease 2

    Background: beta-secretase 1(BACE1) Homo sapiens This gene encodes a member of the peptidase A1 family of aspartic proteases. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protease. This transmembrane protease catalyzes the first step in the formation of amyloid beta peptide from amyloid precursor protein. Amyloid beta peptides are the main constituent of amyloid beta plaques, which accumulate in the brains of human Alzheimer's disease patients. [provided by RefSeq, Nov 2015],

    Gene Name: BACE1

    Protein Name: Beta-secretase 1

    分子量

    55 kDa

    基因ID

    23621

    OMIM

    604252

    UniProt

    P56817
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