MDM4-binding Protein 抗体 (pSer367)
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Quick Overview for MDM4-binding Protein 抗体 (pSer367) (ABIN1532152)
抗原
See all MDM4-binding Protein (MDM4) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 336-385, pSer367
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原理
- MDMX (phospho Ser367) Antibody
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特异性
- Phospho-MDMX (S367) Polyclonal Antibody detects endogenous levels of MDMX protein only when phosphorylated at S367.
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纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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纯度
- > 95 %
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免疫原
- The antiserum was produced against synthesized peptide derived from human MDM4 around the phosphorylation site of Ser367. AA range:336-385
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亚型
- IgG
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anti-Mdm4-binding Protein (MDM4) (AA 1-490) antibody
MDM4 适用: 人 WB, IF, IP 宿主: 兔 Polyclonal unconjugated
anti-Mdm4-binding Protein (MDM4) antibodyMDM4 适用: 人 ELISA, IHC, ICC 宿主: 小鼠 Monoclonal 2D10F4 unconjugated
anti-Mdm4-binding Protein (MDM4) antibodyMDM4 适用: 人 WB, IHC, IF, IHC (p) 宿主: 小鼠 Monoclonal 2D11 unconjugated
anti-Mdm4-binding Protein (MDM4) (AA 125-175) antibodyMDM4 适用: 人 WB, FACS, IP 宿主: 兔 Monoclonal BL-3-2F2 unconjugated Recombinant Antibody
anti-Mdm4-binding Protein (MDM4) (AA 125-175) antibodyMDM4 适用: 人 WB, FACS, IP 宿主: 兔 Monoclonal BL-3-2F2 unconjugated Recombinant Antibody
anti-Mdm4-binding Protein (MDM4) antibodyMDM4 适用: 人 WB, IHC, IF, IHC (p) 宿主: 小鼠 Monoclonal 3A6 unconjugated
anti-Mdm4-binding Protein (MDM4) (AA 1-490) antibodyMDM4 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Mdm4-binding Protein (MDM4) (AA 130-179) antibodyMDM4 适用: 人, Cow, Pig, 兔 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Mdm4-binding Protein (MDM4) (pSer367) antibodyMDM4 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Mdm4-binding Protein (MDM4) (N-Term) antibodyMDM4 适用: 人, 小鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:5000.. IF 1:50-200
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C/1 year
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有效期
- 12 months
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- MDM4-binding Protein (MDM4) (Mdm4-binding Protein (MDM4))
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别名
- MDM4
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背景
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Synonyms: MDM4; MDMX; Protein Mdm4; Double minute 4 protein; Mdm2-like p53-binding protein; Protein Mdmx; p53-binding protein Mdm4
Background: This gene encodes a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus, and shows structural similarity to p53-binding protein MDM2. Both proteins bind the p53 tumor suppressor protein and inhibit its activity, and have been shown to be overexpressed in a variety of human cancers. However, unlike MDM2 which degrades p53, this protein inhibits p53 by binding its transcriptional activation domain. This protein also interacts with MDM2 protein via the RING finger domain, and inhibits the latter's degradation. So this protein can reverse MDM2-targeted degradation of p53, while maintaining suppression of p53 transactivation and apoptotic functions. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Feb 2011],
Gene Name: MDM4
Protein Name: Protein Mdm4
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分子量
- 54 kDa
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基因ID
- 4194
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OMIM
- 602704
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UniProt
- O15151
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途径
- Cell Division Cycle
抗原
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