ATP1A1 抗体 (pSer23)
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Quick Overview for ATP1A1 抗体 (pSer23) (ABIN1531707)
抗原
See all ATP1A1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 15-64, pSer23
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原理
- Na+/K+-ATPase α1 (phospho Ser23) Antibody
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特异性
- Phospho-Na+/K+-ATPase α1 (S23) Polyclonal Antibody detects endogenous levels of Na+/K+-ATPase α1 protein only when phosphorylated at S23.
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纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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纯度
- > 95 %
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免疫原
- The antiserum was produced against synthesized peptide derived from rat ATP1 alpha1/Na+K+ ATPase1 around the phosphorylation site of Ser23. AA range:15-64
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亚型
- IgG
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应用备注
- WB 1:500 - 1:2000. IF 1:100 - 1:300. ELISA: 1:5000. Not yet tested in other applications.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C/1 year
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有效期
- 12 months
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- ATP1A1 (Sodium Potassium ATPase, alpha1 (ATP1A1))
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别名
- ATP1 Alpha1/Na+K+ ATPase1
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背景
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Synonyms: ATP1A1, Sodium/potassium-transporting ATPase subunit alpha-1, Na(+)/K(+) ATPase alpha-1 subunit, Sodium pump subunit alpha-1
Background: The ATPase Na+/K+ transporting subunit alpha 1 encoded by ATP1A1 belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes.This gene encodes an alpha 1 subunit. Multiple transcript variants encoding different isoforms have been found for this gene.
Gene Name: ATP1A1
Protein Name: Sodium/potassium-transporting ATPase subunit alpha-1
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分子量
- 113 kDa
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UniProt
- P05023
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途径
- Thyroid Hormone Synthesis, Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Proton Transport, Ribonucleoside Biosynthetic Process
抗原
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