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CXCR2 抗体 (pSer347)

This 兔 多克隆 antibody specifically detects CXCR2 in WB, IHC, ELISA 和 IF. It exhibits reactivity toward 人.
产品编号 ABIN1531669
发货至: 中国
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Quick Overview for CXCR2 抗体 (pSer347) (ABIN1531669)

抗原

See all CXCR2 抗体
CXCR2 (Chemokine (C-X-C Motif) Receptor 2 (CXCR2))

适用

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人

宿主

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兔

克隆类型

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多克隆

标记

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This CXCR2 antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)
  • 抗原表位

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    AA 311-360, pSer347

    原理

    IL-8Rβ (phospho Ser347) Antibody

    特异性

    Phospho-IL-8Rβ (S347) Polyclonal Antibody detects endogenous levels of IL-8Rβ protein only when phosphorylated at S347.

    纯化方法

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

    纯度

    > 95 %

    免疫原

    The antiserum was produced against synthesized peptide derived from human IL-8R beta/CDw128 beta around the phosphorylation site of Ser347. AA range:311-360

    亚型

    IgG
  • 应用备注

    WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    1 mg/mL

    缓冲液

    Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    Store at -20°C/1 year

    有效期

    12 months
  • 抗原

    CXCR2 (Chemokine (C-X-C Motif) Receptor 2 (CXCR2))

    别名

    IL-8R beta/cdw128 beta

    背景

    Synonyms: CXCR2, IL8RB, C-X-C chemokine receptor type 2, CXC-R2, CXCR-2, CDw128b, GRO/MGSA receptor, High affinity interleukin-8 receptor B, IL-8R B, IL-8 receptor type 2, CD antigen CD182

    Background: C-X-C motif chemokine receptor 2(CXCR2) Homo sapiens The protein encoded byThis gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as

    Gene Name: CXCR2

    Protein Name: C-X-C chemokine receptor type 2

    分子量

    40 kDa

    基因ID

    3579

    OMIM

    146928

    UniProt

    P25025

    途径

    cAMP Metabolic Process
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