ESR2 抗体 (pSer105)
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Quick Overview for ESR2 抗体 (pSer105) (ABIN1531594)
抗原
See all ESR2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 71-120, pSer105
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原理
- ERβ (phospho Ser105) Antibody
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特异性
- Phospho-ERβ (S105) Polyclonal Antibody detects endogenous levels of ERβ protein only when phosphorylated at S105.
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纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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纯度
- > 95 %
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免疫原
- The antiserum was produced against synthesized peptide derived from human Estrogen Receptor-beta around the phosphorylation site of Ser105. AA range:71-120
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亚型
- IgG
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应用备注
- WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:5000. Not yet tested in other applications.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C/1 year
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有效期
- 12 months
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- ESR2 (Estrogen Receptor 2 (ESR2))
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别名
- Estrogen Receptor-beta
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背景
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Synonyms: ESR2, ESTRB, NR3A2, Estrogen receptor beta, ER-beta, Nuclear receptor subfamily 3 group A member 2
Background: This gene encodes a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors. The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus, cytoplasm, and mitochondria. Upon binding to 17beta-estradiol or related ligands, the encoded protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription. Some isoforms dominantly inhibit the activity of other estrogen receptor family members. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been fully characterized. [provided by RefSeq, Jul 2008],
Gene Name: ESR2
Protein Name: Estrogen receptor beta
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分子量
- 59 kDa
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基因ID
- 2100
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OMIM
- 601663
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UniProt
- Q92731
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途径
- Nuclear Receptor Transcription Pathway, EGFR Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling
抗原
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