PDE4D 抗体 (pSer190)
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Quick Overview for PDE4D 抗体 (pSer190) (ABIN1531369)
抗原
See all PDE4D 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 156-205, pSer190
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原理
- PDE4B/C/D (phospho Ser133/119/190) Antibody
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特异性
- Phospho-PDE4B/C/D (S133/119/190) Polyclonal Antibody detects endogenous levels of PDE4B/C/D protein only when phosphorylated at S133/119/190.
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纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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纯度
- > 95 %
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免疫原
- The antiserum was produced against synthesized peptide derived from human PDE4D around the phosphorylation site of Ser190/53. AA range:156-205
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亚型
- IgG
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应用备注
- WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C/1 year
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有效期
- 12 months
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- PDE4D (phosphodiesterase 4D, cAMP-Specific (PDE4D))
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别名
- PDE4D
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背景
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Synonyms: PDE4B, DPDE4, cAMP-specific 3', 5'-cyclic phosphodiesterase 4B, DPDE4, PDE32, PDE4C, DPDE1, cAMP-specific 3',5'-cyclic phosphodiesterase 4C, DPDE1, PDE21, PDE4D, DPDE3, cAMP-specific 3',5'-cyclic phosphodiesterase 4D, DPDE3, PDE43
Background: This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. The encoded protein regulates the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014],
Gene Name: PDE4B/PDE4C/PDE4D
Protein Name: cAMP-specific 3',5'-cyclic phosphodiesterase 4D
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分子量
- 91 kDa
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基因ID
- 5144
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OMIM
- 600129
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UniProt
- Q07343
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途径
- Cellular Response to Molecule of Bacterial Origin, cAMP Metabolic Process, Myometrial Relaxation and Contraction, Regulation of G-Protein Coupled Receptor Protein Signaling
抗原
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