BTK 抗体 (pTyr551)
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北京 101111
Quick Overview for BTK 抗体 (pTyr551) (ABIN1531211)
抗原
See all BTK 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 516-565, pTyr551
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原理
- Btk (phospho Tyr551) Antibody
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特异性
- Phospho-Btk (Y551) Polyclonal Antibody detects endogenous levels of Btk protein only when phosphorylated at Y551.
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纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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纯度
- > 95 %
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免疫原
- The antiserum was produced against synthesized peptide derived from human BTK around the phosphorylation site of Tyr551. AA range:516-565
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亚型
- IgG
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应用备注
- WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C/1 year
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有效期
- 12 months
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- BTK (Bruton Agammaglobulinemia tyrosine Kinase (BTK))
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别名
- BTK
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背景
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Synonyms: BTK, AGMX1, ATK, BPK, Tyrosine-protein kinase BTK, Agammaglobulinaemia tyrosine kinase, ATK, B-cell progenitor kinase, BPK, Bruton tyrosine kinase
Background: The protein encoded by this gene plays a crucial role in B-cell development. Mutations in this gene cause X-linked agammaglobulinemia type 1, which is an immunodeficiency characterized by the failure to produce mature B lymphocytes, and associated with a failure of Ig heavy chain rearrangement. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2013],
Gene Name: BTK
Protein Name: Tyrosine-protein kinase BTK
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分子量
- 76 kDa
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基因ID
- 695
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OMIM
- 300300
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UniProt
- Q06187
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途径
- Fc-epsilon Receptor Signaling Pathway, Hormone Transport, Activation of Innate immune Response, Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response, Toll-Like Receptors Cascades, BCR Signaling
抗原
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