This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
注意事项
Avoid freeze / thaw cycles
储存条件
-20 °C
储存方法
Store at -20°C. Avoid freeze / thaw cycles.
抗原
CSK
(C-Src tyrosine Kinase (CSK))
别名
CSK
背景
Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs including LCK, SRC, HCK, FYN, LYN, CSK or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T-cell receptor (TCR and B-cell receptor (BCR by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK.,CSK, tyrosine-protein kinase CSK,B Cell Receptor Signaling Pathway,Immunology & Inflammation,Kinase,Kinase_Tyrosine kinases,Signal Transduction,CSK