UCP2 抗体 (AA 64-113)
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北京 101111
Quick Overview for UCP2 抗体 (AA 64-113) (ABIN1454055)
抗原
See all UCP2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 64-113
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原理
- UCP2 Antibody
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特异性
- UCP2 Polyclonal Antibody detects endogenous levels of UCP2 protein.
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纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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免疫原
- The antiserum was produced against synthesized peptide derived from human UCP2. AA range:64-113
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亚型
- IgG
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应用备注
- WB 1:500-2000 IHC 1:100 - 1:300. ELISA: 1:10000. IF 1:50-200
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C/1 year
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有效期
- 12 months
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- UCP2 (Uncoupling Protein 2 (Mitochondrial, Proton Carrier) (UCP2))
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别名
- UCP2
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背景
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Synonyms: UCP2; SLC25A8; Mitochondrial uncoupling protein 2; UCP 2; Solute carrier family 25 member 8; UCPH
Background: Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed in many tissues, with the greatest expression in skeletal muscle. It is thought to play a role in nonshivering thermogenesis, obesity and diabetes. Chromosomal order is 5'-UCP3-UCP2-3'. [prov
Gene Name: UCP2
Protein Name: Mitochondrial uncoupling protein 2
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分子量
- 33 kDa
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基因ID
- 7351
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OMIM
- 601693
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UniProt
- P55851
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途径
- Negative Regulation of Hormone Secretion, Carbohydrate Homeostasis, Proton Transport
抗原
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