PLAT 抗体 (AA 38-87)
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北京 101111
Quick Overview for PLAT 抗体 (AA 38-87) (ABIN1454007)
抗原
See all PLAT 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 38-87
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原理
- tPA Antibody
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特异性
- TPA Polyclonal Antibody detects endogenous levels of tPA protein.
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纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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免疫原
- The antiserum was produced against synthesized peptide derived from human tPA. AA range:38-87
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亚型
- IgG
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应用备注
- WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C/1 year
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有效期
- 12 months
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- PLAT (Plasminogen Activator, Tissue (PLAT))
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别名
- tPA
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背景
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Synonyms: PLAT, Tissue-type plasminogen activator, t-PA, t-plasminogen activator, tPA, Alteplase, Reteplase
Background: This gene encodes tissue-type plasminogen activator, a secreted serine protease that converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. The encoded preproprotein is proteolytically processed by plasmin or trypsin to generate heavy and light chains. These chains associate via disulfide linkages to form the heterodimeric enzyme. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding, while decreased activity leads to hypofibrinolysis, which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016],
Gene Name: PLAT
Protein Name: Tissue-type plasminogen activator
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分子量
- 62 kDa
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基因ID
- 5327
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OMIM
- 173370
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UniProt
- P00750
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途径
- Autophagy, Smooth Muscle Cell Migration, Platelet-derived growth Factor Receptor Signaling, SARS-CoV-2 Protein Interactome
抗原
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