SOCS1 抗体 (AA 49-98)
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北京 101111
Quick Overview for SOCS1 抗体 (AA 49-98) (ABIN1453935)
抗原
See all SOCS1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 49-98
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原理
- SOCS-1 Antibody
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特异性
- SOCS-1 Polyclonal Antibody detects endogenous levels of SOCS-1 protein.
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纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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免疫原
- The antiserum was produced against synthesized peptide derived from human SOCS-1. AA range:49-98
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亚型
- IgG
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应用备注
- IF 1:50-200 WB 1:500-2000, ELISA 1:10000-20000 IHC 1:50-300
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C/1 year
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有效期
- 12 months
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- SOCS1 (Suppressor of Cytokine Signaling 1 (SOCS1))
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别名
- SOCS-1
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背景
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Synonyms: SOCS1, SSI1, TIP3, Suppressor of cytokine signaling 1, SOCS-1, JAK-binding protein, JAB, STAT-induced STAT inhibitor 1, SSI-1, Tec-interacting protein 3, TIP-3
Background: This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma.The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival. [provided by RefSeq, Jul 2008],
Gene Name: SOCS1
Protein Name: Suppressor of cytokine signaling 1
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分子量
- 23 kDa
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基因ID
- 8651
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OMIM
- 603597
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UniProt
- O15524
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途径
- JAK/STAT Signaling, Interferon-gamma Pathway, TLR signaling, Response to Growth Hormone Stimulus
抗原
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