ABI1 抗体 (AA 152-201)
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北京 101111
Quick Overview for ABI1 抗体 (AA 152-201) (ABIN1452867)
抗原
See all ABI1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 152-201
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原理
- Abi-1 Antibody
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特异性
- Abi-1 Polyclonal Antibody detects endogenous levels of Abi-1 protein.
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纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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免疫原
- The antiserum was produced against synthesized peptide derived from human Abi-1. AA range:152-201
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亚型
- IgG
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应用备注
- WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C/1 year
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有效期
- 12 months
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- ABI1 (Abl-Interactor 1 (ABI1))
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别名
- Abi-1
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背景
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Synonyms: ABI1, SSH3BP1, Abl interactor 1, Abelson interactor 1, Abi-1, Abl-binding protein 4, AblBP4, Eps8 SH3 domain-binding protein, Eps8-binding protein, Nap1-binding protein, Nap1BP, Spectrin SH3 domain-binding protein 1, e3B1
Background: This gene encodes a member of the Abelson-interactor family of adaptor proteins. These proteins facilitate signal transduction as components of several multiprotein complexes, and regulate actin polymerization and cytoskeletal remodeling through interactions with Abelson tyrosine kinases. The encoded protein plays a role in macropinocytosis as a component of the WAVE2 complex, and also forms a complex with EPS8 and SOS1 that mediates signal transduction from Ras to Rac. This gene may play a role in the progression of several malignancies including melanoma, colon cancer and breast cancer, and a t(10,11) chromosomal translocation involving this gene and the MLL gene has been associated with acute myeloid leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 14. [provided by RefSeq
Gene Name: ABI1
Protein Name: Abl interactor 1
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分子量
- 55 kDa
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基因ID
- 10006
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OMIM
- 603050
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UniProt
- Q8IZP0
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途径
- RTK signaling, Response to Water Deprivation, ER-Nucleus Signaling
抗原
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