C1R 抗体 (Cleaved-Arg463)
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北京 101111
Quick Overview for C1R 抗体 (Cleaved-Arg463) (ABIN1452252)
抗原
See all C1R 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 414-463, Cleaved-Arg463
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原理
- Cleaved-C1r HC (R463) Antibody
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特异性
- Cleaved-C1r HC (R463) Polyclonal Antibody detects endogenous levels of fragment of activated C1r HC protein resulting from cleavage adjacent to R463.
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纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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免疫原
- The antiserum was produced against synthesized peptide derived from human C1R. AA range:414-463
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亚型
- IgG
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anti-Complement Component 1, R Subcomponent (C1R) (AA 65-192) antibody
C1R 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Complement Component 1, R Subcomponent (C1R) (AA 1-705) antibodyC1R 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Complement Component 1, R Subcomponent (C1R) antibodyC1R 适用: 人 WB, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Complement Component 1, R Subcomponent (C1R) (AA 466-705) antibodyC1R 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Complement Component 1, R Subcomponent (C1R) (AA 231-430) antibodyC1R 适用: 人 WB, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Complement Component 1, R Subcomponent (C1R) (AA 1-705) antibodyC1R 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Complement Component 1, R Subcomponent (C1R) (AA 262-562) antibodyC1R 适用: 人, 犬 WB, IHC, IHC (p) 宿主: 小鼠 Monoclonal 1F1 unconjugated
anti-Complement Component 1, R Subcomponent (C1R) (AA 445-494), (Cleaved-Ile464) antibodyC1R 适用: 人 WB, ELISA, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Complement Component 1, R Subcomponent (C1R) (cleaved), (Internal Region) antibodyC1R 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C/1 year
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有效期
- 12 months
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- C1R (Complement Component 1, R Subcomponent (C1R))
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别名
- C1R
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背景
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Synonyms: C1R, Complement C1r subcomponent, Complement component 1 subcomponent r
Background: catalytic activity:Selective cleavage of Lys(or Arg)-|-Ile bond in complement subcomponent C1s to form the active form of C1s (EC 3.4.21.42).,function:C1r B chain is a serine protease that combines with C1q and C1s to form C1, the first component of the classical pathway of the complement system.,polymorphism:Complement component C1r deficiency [MIM:216950] leads to the failure of the classical complement system activation pathway (C1 deficiency). Individuals with C1 deficiency are highly susceptible to infections by microorganisms and have greater risk in developing autoimmune diseases such as systemic lupus erythematosus (SLE).,PTM:The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.,similarity:Belongs to the peptidase S1 family.,similarity:Contains 1 EGF-like domain.,similarity:Contains 1 peptidase S1 domain.,similarity:Contains 2 CUB domains.,similarity:Contains 2 Sushi (CCP/SCR) domains.,subunit:C1 is a calcium-dependent trimolecular complex of C1q, C1r and C1s in the molar ration of 1:2:2. C1r is a dimer of identical chains, each of which is activated by cleavage into two chains, A and B, connected by disulfide bonds.,
Gene Name: C1R
Protein Name: Complement C1r subcomponent
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分子量
- 80 kDa
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基因ID
- 715
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OMIM
- 216950
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UniProt
- P00736
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途径
- Complement System
抗原
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