RNF111 抗体 (AA 901-950)
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北京 101111
Quick Overview for RNF111 抗体 (AA 901-950) (ABIN1451235)
抗原
See all RNF111 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 901-950
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原理
- Arkadia Antibody
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特异性
- Arkadia Polyclonal Antibody detects endogenous levels of Arkadia protein.
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纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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免疫原
- The antiserum was produced against synthesized peptide derived from human RNF111. AA range:901-950
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亚型
- IgG
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应用备注
- WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C/1 year
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有效期
- 12 months
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- RNF111 (Ring Finger Protein 111 (RNF111))
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别名
- RNF111
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背景
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Synonyms: RNF111, E3 ubiquitin-protein ligase Arkadia, RING finger protein 111
Background: ring finger protein 111(RNF111) Homo sapiens The protein encoded by this gene is a nuclear RING-domain containing E3 ubiquitin ligase. This protein interacts with the transforming growth factor (TGF) -beta/NODAL signaling pathway by promoting the ubiquitination and proteosomal degradation of negative regulators, like SMAD proteins, and thereby enhances TGF-beta target-gene transcription. As a modulator of the nodal signaling cascade, this gene plays a critical role in the induction of mesoderm during embryonic development. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2012],
Gene Name: RNF111
Protein Name: E3 ubiquitin-protein ligase Arkadia
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分子量
- 108 kDa
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基因ID
- 54778
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OMIM
- 605840
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UniProt
- Q6ZNA4
抗原
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