KEAP1 抗体 (C-Term)
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北京 101111
Quick Overview for KEAP1 抗体 (C-Term) (ABIN1449975)
抗原
See all KEAP1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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纯化方法
- Affinity chromatography purified via peptide column
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免疫原
- A 19 amino acid synthetic peptide near the carboxy terminus of Human KEAP1
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亚型
- IgG
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anti-Kelch-Like ECH-Associated Protein 1 (KEAP1) antibody
KEAP1 适用: 人, 小鼠 WB, IHC, IHC (p), FACS 宿主: 小鼠 Monoclonal 1B4 unconjugated
anti-Kelch-Like ECH-Associated Protein 1 (KEAP1) (AA 380-624) antibodyKEAP1 适用: 人 ELISA, IHC, FACS 宿主: 小鼠 Monoclonal 7G4B10 unconjugated
anti-Kelch-Like ECH-Associated Protein 1 (KEAP1) (AA 380-624) antibodyKEAP1 适用: 人, 小鼠 ELISA, ICC, FACS 宿主: 小鼠 Monoclonal 1F10B6 unconjugated
anti-Kelch-Like ECH-Associated Protein 1 (KEAP1) (AA 380-624) antibodyKEAP1 适用: 人 WB, ELISA, IHC, FACS 宿主: 小鼠 Monoclonal unconjugated
anti-Kelch-Like ECH-Associated Protein 1 (KEAP1) (C-Term) antibodyKEAP1 适用: 人, 小鼠, 大鼠, 兔, Cow, 犬, 马, 豚鼠, 斑马鱼 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Kelch-Like ECH-Associated Protein 1 (KEAP1) (AA 65-160) antibodyKEAP1 适用: 人, 小鼠, 大鼠, Pig, 兔 WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Kelch-Like ECH-Associated Protein 1 (KEAP1) (AA 327-624) antibodyKEAP1 适用: 人 WB, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Kelch-Like ECH-Associated Protein 1 (KEAP1) (AA 1-286) antibodyKEAP1 适用: 小鼠 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Kelch-Like ECH-Associated Protein 1 (KEAP1) (AA 41-53) antibodyVerified KEAP1 适用: 人 ELISA, IHC, IF 宿主: 山羊 Polyclonal unconjugated
anti-Kelch-Like ECH-Associated Protein 1 (KEAP1) antibodyKD Validated KEAP1 适用: 人 WB, FACS 宿主: 小鼠 Monoclonal 25GB495 unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- PBS containing 0.02 % Sodium Azide as preservative
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- KEAP1 (Kelch-Like ECH-Associated Protein 1 (KEAP1))
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别名
- KEAP1
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背景
- KEAP1 (kelch-like ECH-associated protein 1) is a stress sensing adaptor for the Cullin3 (Cul3)-dependent E3 ubiquitin ligase complex that negatively regulates NRF2 (NF-E2-related factor 2) and plays a role in the oxidative stress response. It targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome. KEAP1 contains an amino terminal BTB/POZ domain and a carboxyl terminal KELCH domain which are required for interaction with NRF2, and in binding Cul3-E3 ubiquitin ligase. Altered expression of NRF2 is associated with chronic obstructive pulmonary disease (COPD). KEAP1 also targets the down regulation of NF-kB activity by targeting IKKbeta degradation. Mutation of the KEAP1 gene is found in lung cancer.Synonyms: Cytosolic inhibitor of Nrf2, INRF2, INrf2, KEAP1, KIAA0132, KLHL19, Kelch-like ECH-associated protein 1, Kelch-like protein 19
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分子量
- 69 kDa
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基因ID
- 9817
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NCBI登录号
- NP_987096
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途径
- Maintenance of Protein Location
抗原
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