HMGB1 抗体 (Internal Region)
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Quick Overview for HMGB1 抗体 (Internal Region) (ABIN1449284)
抗原
See all HMGB1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- Internal Region
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特异性
- This antibody reacts with HMGB1.
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交叉反应 （详细）
- Species reactivity (tested):Human, Mouse, Rat
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纯化方法
- Protein A agarose
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免疫原
- Synthetic peptide corresponding to internal region of human HMGB1
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亚型
- IgG
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anti-High Mobility Group Box 1 (HMGB1) (AA 75-170) antibody
HMGB1 适用: 人, 小鼠, 大鼠 WB, ELISA, FACS, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-High Mobility Group Box 1 (HMGB1) (AA 1-90) antibodyHMGB1 适用: 人 WB, ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 2F6 unconjugated
anti-High Mobility Group Box 1 (HMGB1) antibodyKO Validated HMGB1 适用: 人 WB, IHC, IF, ICC, IHC (p), IHC (wm), IHC (ff) 宿主: 兔 Polyclonal unconjugated
anti-High Mobility Group Box 1 (HMGB1) (AA 9-163) antibodyHMGB1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-High Mobility Group Box 1 (HMGB1) (AA 1-215) antibodyHMGB1 适用: 小鼠 WB, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-High Mobility Group Box 1 (HMGB1) (AA 1-215) antibodyHMGB1 适用: 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-High Mobility Group Box 1 (HMGB1) (AA 1-215) antibodyHMGB1 适用: 人 WB, ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 1E6-E10 unconjugated
anti-High Mobility Group Box 1 (HMGB1) (AA 1-215) antibodyHMGB1 适用: 人 WB, ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 1D5 unconjugated
anti-High Mobility Group Box 1 (HMGB1) (AA 124-154), (C-Term) antibodyHMGB1 适用: 人, 小鼠, 大鼠 WB, IHC, IF, ICC, FACS 宿主: 兔 Polyclonal unconjugated
anti-High Mobility Group Box 1 (HMGB1) (AA 1-215) antibodyHMGB1 适用: 人 WB, IF, ICC 宿主: 小鼠 Monoclonal C4 unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- PBS containing 50 % glycerol, pH 7.2. No preservative is contained.
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储存液
- Without preservative
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- -20 °C
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储存方法
- Upon receipt, store (in aliqouts) at -20 °C.
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- HMGB1 (High Mobility Group Box 1 (HMGB1))
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别名
- HMGB1
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背景
- High mobility group box 1 (HMGB1), named for its rapid migration properties on electrophoretic gels, is a member of the nonhistone chromatin-associated proteins. HMGB1 is translated as a 214 amino acid protein, and extensively modified posttranslationally, by glycosylation, acylation, methylation, and phosphorylation. The primary structure is evolutionarily conserved, with 100 % amino acid sequence homology between rat and mouse, and 99 % homology between rodent and human. Intracellular HMGB1 has been studied previously for its roles in binding DNA, stabilizing nucleosome formation, as a general transcription factor for nucleolar and mitochondrial RNA polymerases, and as a gene- and tissue-specific transcriptional regulator that can enhance transcription and/or replication. Extracellular HMGB1 is recently implicated as a late mediator of delayed endotoxin lethality, because murine and human macrophages/monocytes release large amounts of a 29 kDa form of HMGB1 when stimulated by exposure to bacterial endotoxin.Synonyms: Amphoterin, HMG-1, HMG1, HMGB-1, High mobility group protein 1, High mobility group protein B1
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基因ID
- 3146
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NCBI登录号
- NP_002119
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UniProt
- P09429
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途径
- p53 Pathway, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Toll-Like Receptors Cascades, Smooth Muscle Cell Migration, Inflammasome
抗原
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