电话:
+86 (0512) 65829739
传真:
+86 (010) 6788 5057
电子邮件:
orders@antibodies-online.cn

HMGB1 抗体 (Internal Region)

This anti-HMGB1 antibody is a 小鼠 单克隆 antibody detecting HMGB1 in WB. Suitable for 人, 小鼠 和 大鼠.
产品编号 ABIN1449284
发货至: 中国

Quick Overview for HMGB1 抗体 (Internal Region) (ABIN1449284)

抗原

See all HMGB1 抗体
HMGB1 (High Mobility Group Box 1 (HMGB1))

适用

  • 176
  • 99
  • 99
  • 13
  • 13
  • 13
  • 11
  • 8
  • 7
  • 7
  • 6
  • 6
  • 5
  • 2
  • 1
  • 1
  • 1
人, 小鼠, 大鼠

宿主

  • 156
  • 44
  • 2
  • 2
  • 2
  • 1
  • 1
小鼠

克隆类型

  • 144
  • 64
单克隆

标记

  • 118
  • 20
  • 19
  • 6
  • 5
  • 5
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
This HMGB1 antibody is un-conjugated

应用范围

  • 175
  • 81
  • 66
  • 51
  • 47
  • 41
  • 30
  • 27
  • 26
  • 24
  • 9
  • 5
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Western Blotting (WB)

克隆位点

4C9
  • 抗原表位

    • 33
    • 16
    • 16
    • 11
    • 9
    • 7
    • 7
    • 6
    • 5
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region

    特异性

    This antibody reacts with HMGB1.

    交叉反应 (详细)

    Species reactivity (tested):Human, Mouse, Rat

    纯化方法

    Protein A agarose

    免疫原

    Synthetic peptide corresponding to internal region of human HMGB1

    亚型

    IgG
  • 应用备注

    Optimal working dilution should be determined by the investigator.

    限制

    仅限研究用
  • 浓度

    1.0 mg/mL

    缓冲液

    PBS containing 50 % glycerol, pH 7.2. No preservative is contained.

    储存液

    Without preservative

    注意事项

    Avoid repeated freezing and thawing.

    储存条件

    -20 °C

    储存方法

    Upon receipt, store (in aliqouts) at -20 °C.
  • 抗原

    HMGB1 (High Mobility Group Box 1 (HMGB1))

    别名

    HMGB1

    背景

    High mobility group box 1 (HMGB1), named for its rapid migration properties on electrophoretic gels, is a member of the nonhistone chromatin-associated proteins. HMGB1 is translated as a 214 amino acid protein, and extensively modified posttranslationally, by glycosylation, acylation, methylation, and phosphorylation. The primary structure is evolutionarily conserved, with 100 % amino acid sequence homology between rat and mouse, and 99 % homology between rodent and human. Intracellular HMGB1 has been studied previously for its roles in binding DNA, stabilizing nucleosome formation, as a general transcription factor for nucleolar and mitochondrial RNA polymerases, and as a gene- and tissue-specific transcriptional regulator that can enhance transcription and/or replication. Extracellular HMGB1 is recently implicated as a late mediator of delayed endotoxin lethality, because murine and human macrophages/monocytes release large amounts of a 29 kDa form of HMGB1 when stimulated by exposure to bacterial endotoxin.Synonyms: Amphoterin, HMG-1, HMG1, HMGB-1, High mobility group protein 1, High mobility group protein B1

    基因ID

    3146

    NCBI登录号

    NP_002119

    UniProt

    P09429

    途径

    p53 Pathway, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Toll-Like Receptors Cascades, Smooth Muscle Cell Migration, Inflammasome
You are here:
Chat with us!