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PD-L1 抗体 (Extracellular Domain)

Name: PD-L1 抗体 (Extracellular Domain)
SKU: ABIN1449244
Availability: OutOfStock

This anti-PD-L1 antibody is a 小鼠单克隆 antibody detecting PD-L1 in FACS 和 IHC (p). Suitable for 人. This Primary Antibody has been cited in 6+ publications.

Immunohistochemistry (IHC) image for anti-CD274 (PD-L1) (Extracellular Domain) antibody (ABIN1449244) (PD-L1 抗体 (Extracellular Domain))

IHC

FACS

2 images

(6 references)

产品编号 ABIN1449244

发货至: 中国

Quick Overview for PD-L1 抗体 (Extracellular Domain) (ABIN1449244)

抗原

See all PD-L1 抗体

PD-L1 (CD274 (PD-L1))

适用

人

宿主

小鼠

克隆类型

单克隆

标记

This PD-L1 antibody is un-conjugated

应用范围

Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

克隆位点

27A2

Discover our top product PD-L1 Primary Antibody

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Extracellular Domain

特异性

This antibody reacts with human CD274 antigen.

纯化方法

Protein A agarose

免疫原

Recombinant human PD-L1 extracellular domain

亚型

IgG2b
anti-CD274 (PD-L1) (C-Term) antibody
Verified PD-L1 适用: 人 WB, FACS, ELISA, IF 宿主: 山羊 Polyclonal unconjugated

anti-CD274 (PD-L1) (AA 19-238) antibody
PD-L1 适用: 人 WB, FACS, IHC, ELISA, IF 宿主: 小鼠 Monoclonal 9B5F4 unconjugated

anti-CD274 (PD-L1) (AA 39-191) antibody
PD-L1 适用: 人, 小鼠 WB, FACS, IHC, ELISA, IF, Coat, StM 宿主: 小鼠 Monoclonal PDL1-2746 unconjugated

anti-CD274 (PD-L1) (AA 24-153) antibody
PD-L1 适用: 人 FACS, IHC, ELISA 宿主: 小鼠 Monoclonal 6D9A2 unconjugated

anti-CD274 (PD-L1) (AA 48-290) antibody
PD-L1 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-CD274 (PD-L1) (AA 34-241) antibody
PD-L1 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-CD274 (PD-L1) (AA 19-238) antibody
PD-L1 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-CD274 (PD-L1) (C-Term) antibody
KO Validated PD-L1 适用: 人 WB, FACS, IF, ICC, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-CD274 (PD-L1) (AA 24-153) antibody
PD-L1 适用: 人 FACS, ELISA 宿主: 小鼠 Monoclonal 7D2A10 unconjugated

anti-CD274 (PD-L1) (AA 201-290) antibody
PD-L1 适用: 小鼠, 大鼠 WB, ELISA, IF (cc), IHC (p), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

应用备注

Optimal working dilution should be determined by the investigator.

限制

仅限研究用
浓度

1.0 mg/mL

缓冲液

PBS containing 50 % glycerol, pH 7.2. No preservative is contained.

储存液

Without preservative

注意事项

Avoid repeated freezing and thawing.

储存条件

-20 °C

储存方法

Upon receipt, store (in aliqouts) at -20 °C.
Gadiot, Hooijkaas, Kaiser, van Tinteren, van Boven, Blank: "Overall survival and PD-L1 expression in metastasized malignant melanoma." in: Cancer, Vol. 117, Issue 10, pp. 2192-201, (2011) (PubMed).

Hino, Kabashima, Kato, Yagi, Nakamura, Honjo, Okazaki, Tokura: "Tumor cell expression of programmed cell death-1 ligand 1 is a prognostic factor for malignant melanoma." in: Cancer, Vol. 116, Issue 7, pp. 1757-66, (2010) (PubMed).

Schuchmann, Meyer, Distler, von Stebut, Kuball, Schnürer, Wölfel, Theobald, Konur, Gregor, Schreiner, Huber, Galle, Otto, Herr: "The programmed death (PD)-1/PD-ligand 1 pathway regulates graft-versus-host-reactive CD8 T cells after liver transplantation." in: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, Vol. 8, Issue 11, pp. 2434-44, (2008) (PubMed).

Fancke, Suter, Hochrein, OKeeffe: "M-CSF: a novel plasmacytoid and conventional dendritic cell poietin." in: Blood, Vol. 111, Issue 1, pp. 150-9, (2008) (PubMed).

Hamanishi, Mandai, Iwasaki, Okazaki, Tanaka, Yamaguchi, Higuchi, Yagi, Takakura, Minato, Honjo, Fujii: "Programmed cell death 1 ligand 1 and tumor-infiltrating CD8+ T lymphocytes are prognostic factors of human ovarian cancer." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, Issue 9, pp. 3360-5, (2007) (PubMed).

Vega, Jazirehi, Huerta-Yepez, Bonavida et al.: "Rituximab-induced inhibition of YY1 and Bcl-xL expression in Ramos non-Hodgkin's lymphoma cell line via inhibition of NF-kappa B activity: role of YY1 and Bcl-xL in Fas resistance and ..." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 175, Issue 4, pp. 2174-83, (2005) (PubMed).
抗原

PD-L1 (CD274 (PD-L1))

别名

CD274 / PDL1

背景

Programmed death ligand 1 (PD-L1, also known as CD274/B7-H1), a member of B7 family was identified by searching for mo lecules that share homology with the immunogloblin V and C domains of B7-1 and B7-2 among the human cDNA expressed sequence tags in the National Center for Biotechnology Information database. PD-L1 is a ligand for programmed death 1 (PD-1) which belongs to the CD28/CTLA4 subfamily. Although in vitro study indicated that the cross-linking of PD-1 by PD-L1 leads to down-regulation of T-cell responses, some studies have shown that T cells stimulated with low levels of anti-CD3 and immobilized PD-L1-Ig were activated, proliferation and production of IFN- γ GM-CSF and IL-10 from the T cells were enhanced. The role of PD-L1 is now debatable.Synonyms: B7 homolog 1, B7H1, PD-L1, PDCD1 ligand 1, PDCD1L1, PDCD1LG1, Programmed cell death 1 ligand 1, Programmed death ligand 1

基因ID

29126

NCBI登录号

NP_054862

UniProt

Q9NZQ7

途径

Cancer Immune Checkpoints