TLR4 抗体 (PE)
Quick Overview for TLR4 抗体 (PE) (ABIN1449236)
抗原
See all TLR4 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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特异性
- This antibody reacts with mouse TLR4/MD-2 complex.
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纯化方法
- Protein A agarose
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免疫原
- Mouse TLR4/MD-2 transfected Ba/F3 cell
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亚型
- IgG1
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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缓冲液
- 50 tests in 1 mLPBS containing 1 % BSA and 0.09 % NaN3
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- Store at 2-8 °C.
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- TLR4 (Toll-Like Receptor 4 (TLR4))
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别名
- CD284 / TLR4
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背景
- Toll, a Drosophila receptor molecule with extracellular leucine-rich repeat (LRR), has a role in triggering innate defenses against bacteria or fungi. TLR4 (Toll-like receptor 4) is a member of TLR family, which is human homologue of Toll protei n. It has extracellular LRR and an intracellular signaling domain, which is similar to the type I IL-1 receptor. TLR4 is expressed in subpopulations of cells including myeloid cells, B cells, monocytes, and endothelial cells. Recent studies have suggested that TLR4 might act as a receptor for LPS (lipopolysaccharide). TLR4 alone is not capable of sensing and signaling the presence of LPS, but another molecule MD-2, which is physically associated with TLR4, is required for LPS recognition through TLR4.Synonyms: Toll-like receptor 4
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基因ID
- 21898
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NCBI登录号
- NP_067272
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UniProt
- Q9QUK6
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途径
- TLR signaling, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Toll-Like Receptors Cascades, Inflammasome, S100 Proteins
抗原
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