CD226 抗体 (FITC)
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北京 101111
Quick Overview for CD226 抗体 (FITC) (ABIN1449203)
抗原
See all CD226 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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特异性
- This antibody reacts with human CD226/DNAM-1.
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纯化方法
- Protein G agarose
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免疫原
- Recombinant human CD226/DNAM-1
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亚型
- IgG2a
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 0.5 mg/mL
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缓冲液
- PBS, 0.09 % NaN3, 1 % BSA
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- Store at 2-8 °C.
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- CD226
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别名
- CD226 / DNAM1
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背景
- CD226/DNAM-1 (DNAX accessory molecule-1) is a 65 kDa type I transmembrane glycoprotein expressed on the majority of T cells, NK cells, monocytes, and a subset of B-cells. A soluble form (50 kDa) of CD226 is present in normal serum and the supernatant of cultured activated T cells. Ligand binding to CD226 results in phosphorylation of Ser329 and Tyr322, suggesting a role in signal transduction. CD226 acts as an adhesion molecule involved in the binding of certain tumor cells to CTL and NK cells and mediates their cytotoxicity. CD226 also stimulates TNF-α and IFN-γ secretion by alloantigen-specific T cells.Synonyms: DNAM-1, DNAX accessory molecule 1
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基因ID
- 10666
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NCBI登录号
- NP_006557
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UniProt
- Q15762
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途径
- Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Cancer Immune Checkpoints
抗原
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