GFI1B 抗体 (Cy5)
Quick Overview for GFI1B 抗体 (Cy5) (ABIN1423080)
抗原
See all GFI1B 抗体适用
宿主
克隆类型
标记
应用范围
-
-
交叉反应
- 人, 小鼠, 大鼠
-
纯化方法
- Purified by Protein A.
-
免疫原
- KLH conjugated synthetic peptide derived from human GFI1B
-
亚型
- IgG
-
-
anti-Growth Factor Independent 1B Transcription Repressor (GFI1B) (N-Term) antibody
GFI1B 适用: 人, 小鼠, 大鼠, Cow, 犬, 马 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Growth Factor Independent 1B Transcription Repressor (GFI1B) (Internal Region) antibodyGFI1B 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Growth Factor Independent 1B Transcription Repressor (GFI1B) (N-Term) antibodyGFI1B 适用: 人, 小鼠, 大鼠, Cow, 犬, 马, 山羊, Pig WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Growth Factor Independent 1B Transcription Repressor (GFI1B) antibodyGFI1B 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Growth Factor Independent 1B Transcription Repressor (GFI1B) (AA 2-110) antibodyGFI1B 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Growth Factor Independent 1B Transcription Repressor (GFI1B) (AA 1-330) antibodyGFI1B 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Growth Factor Independent 1B Transcription Repressor (GFI1B) (Internal Region) antibodyGFI1B 适用: 人 WB, ELISA, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Growth Factor Independent 1B Transcription Repressor (GFI1B) (AA 302-330), (C-Term) antibodyGFI1B 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal RB44051 unconjugated
-
-
应用备注
- IF(IHC-P) 1:50-200
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
浓度
- 1 μg/μL
-
缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
-
储存液
- ProClin
-
注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
-
储存条件
- -20 °C
-
储存方法
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
-
有效期
- 12 months
-
-
- GFI1B (Growth Factor Independent 1B Transcription Repressor (GFI1B))
-
别名
- GFI1B
-
背景
-
Synonyms: Potential regulator of CDKN1A translocated in CML, GFI 1B, GFI-1B, gfi1b, GFI1B protein, GFI1B_HUMAN, Growth factor independent 1B protein, Growth factor independent protein 1B, Potential regulator of CDKN1A, Translocated in CML, Zinc finger protein Gfi-1b.
Background: Essential proto-oncogenic transcriptional regulator necessary for development and differentiation of erythroid and megakaryocytic lineages. Transcriptional repressor or activator depending on both promoter and cell type context, represses promoter activity of SOCS1 and SOCS3 and thus, may regulate cytokine signaling pathways. Cooperates with GATA1 to repress target gene transcription, such as the apoptosis regulator BCL2L1, GFI1B silencing in leukemic cell lines markedly increase apoptosis rate. Inhibits down-regulation of MYC and MYB as well as the cyclin-dependent kinase inhibitor CDKN1A/P21WAF1 in IL6-treated myelomonocytic cells. Represses expression of GATA3 in T-cell lymphomas and inhibits GATA1-mediated transcription, as GATA1 also mediates erythroid GFI1B transcription, both GATA1 and GFI1B participate in a feedback regulatory pathway controlling the expression of GFI1B gene in erythroid cells. Suppresses GATA1-mediated stimulation of GFI1B promoter through protein interaction. Binds to gamma-satellite DNA and to its own promoter, auto-repressing its own expression. Alters histone methylation by recruiting histone methyltransferase to target genes promoters. Plays a role in heterochromatin formation.
-
基因ID
- 8328
-
途径
- Cellular Response to Molecule of Bacterial Origin
抗原
-
